Results 51 to 60 of about 578,139 (333)

Passive smoking indicators in Italy: does the gross domestic product matter? [PDF]

, 2018
BACKGROUND: The aim of this study is to analyse the correlation between regional values of Gross Domestic Product (GDP) and passive smoking in Italy.
Cianfanelli, Sara, Cocchiara, Rosario Andrea, La Torre, Giuseppe, Lia, Lorenza, Mannocci, Alice, Sestili, Cristina   +5 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Policy windows, ambiguity and Commission entrepreneurship: explaining the relaunch of the European Union's economic reform agenda [PDF]

, 2014
This article explains the relaunch of the European Union's (EU) economic reform agenda in 2010. After repeated delays during 2009, the European Commission scaled back its initial plan for a revived social dimension and instead proposed a strengthened ...

core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Impact of body mass index on the efficacy and safety of ipragliflozin in Japanese patients with type 2 diabetes mellitus: A subgroup analysis of 3‐month interim results from the Specified Drug Use Results Survey of Ipragliflozin Treatment in Type 2 Diabetic Patients: Long‐term Use study

Journal of Diabetes Investigation, 2019
Aims/Introduction Specified Drug Use Results Survey of Ipragliflozin Treatment in Type 2 Diabetic Patients: Long‐term Use is an ongoing postmarketing study of ipragliflozin for long‐term use in Japanese patients with type 2 diabetes mellitus.
Kazuyuki Tobe, Hiroshi Maegawa, Hiromi Tabuchi, Ichiro Nakamura, Satoshi Uno   +4 more
doaj   +1 more source

The safety assessment of tampons: illustration of a comprehensive approach for four different products

Frontiers in Reproductive Health, 2023
IntroductionWe illustrate a comprehensive tampon safety assessment approach that assures products can be used safely. Material biocompatibility, vaginal mucosa assessment, vaginal microbiome evaluation, and in vitro assessment of potential risk of ...
Anne E. Hochwalt, Joan M. Abbinante-Nissen, Lisa C. Bohman, Anne M. Hattersley, Ping Hu, Jan L. Streicher-Scott, Amber G. Teufel, Kara E. Woeller   +7 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reality check: testing the in silico predictions of false negative results due to mutations in SARS-CoV-2 PCR assays using templates with mismatches in vitro

Frontiers in Cellular and Infection Microbiology
Molecular diagnostic assays are critical tools to test, diagnose and treat infectious and other diseases. For example, PCR test results have been extremely valuable during the COVID-19 pandemic, not only to provide appropriate health care for infected ...
Taylor Otwell, Brittany Knight, Michael Coryell, Jennifer Stone, Jennifer Stone, Phillip Davis, Bryan Necciai, Paul Carlson, Shanmuga Sozhamannan, Shanmuga Sozhamannan   +9 more
doaj   +1 more source

Scalable Surveillance of E-Cigarette Products on Instagram and TikTok Using Computer Vision [PDF]

, 2023
Julia Vassey, Chris J. Kennedy, Ho-Chun Herbert Chang, Ashley Smith, Jennifer B. Unger   +4 more
openalex   +1 more source

Approximate Computation of DFT without Performing Any Multiplications: Applications to Radar Signal Processing

, 2014
In many practical problems it is not necessary to compute the DFT in a perfect manner including some radar problems. In this article a new multiplication free algorithm for approximate computation of the DFT is introduced. All multiplications $(a\times b)
Akbas, Cem Emre, Arslan, Musa Tunç, Bozkurt, Alican, Sevimli, Rasim Akin, Çetin, A. Enis   +4 more
core   +1 more source