Results 51 to 60 of about 774,784 (264)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Including Lifetime Hydraulic Turbine Cost into Short-Term Hybrid Scheduling of Hydro and Solar
EnergiesIn traditional short-term hydropower scheduling problems, which usually determine the optimal power generation schedules within one week, the off-design zone of a hydraulic turbine is modeled as a forbidden zone due to the significantly increased risk of
Jiehong Kong +2 more
doaj +1 more source
Identification and quantification of benchmarks of milk production systems in Minas Gerais
Revista Brasileira de Zootecnia, 2012 The objective of this study was to identify and quantify benchmarks of milk production systems. The technological profile and size, livestock and economic indicators of sixteen farms in the region of Triângulo Mineiro were analyzed. Indicators correlated
Matozalém Camilo Neto +3 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Acta Scientiarum: Animal Sciences, 2010 O objetivo foi avaliar a viabilidade financeira do fornecimento de cinco suplementos elaborados com diferentes fontes de óleo e proteína para abelhas africanizadas submetidas à produção de geleia real.
Fabiana Martins Costa Maia +5 more
doaj
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2005 Estudou-se a rentabilidade da terminação de bovinos de corte em confinamento, calculou-se o custo de produção e identificaram-se os componentes de maior influência sobre o custo operacional efetivo da arroba de carne.
M.A. Lopes, G.P. Magalhães
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source