Results 31 to 40 of about 59,950 (263)

Computational Tools for Discovering and Engineering Natural Product Biosynthetic Pathways [PDF]

open access: yesiScience, 2020
Natural products (NPs), also known as secondary metabolites, are produced in bacteria, fungi, and plants. NPs represent a rich source of antibacterial, antifungal, and anticancer agents. Recent advances in DNA sequencing technologies and bioinformatics unveiled nature's great potential for synthesizing numerous NPs that may confer unprecedented ...
Hengqian Ren, Chengyou Shi, Huimin Zhao
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

TDD-net: a tiny defect detection network for printed circuit boards

open access: yesCAAI Transactions on Intelligence Technology, 2019
Tiny defect detection (TDD) which aims to perform the quality control of printed circuit boards (PCBs) is a basic and essential task in the production of most electronic products.
Runwei Ding   +3 more
doaj   +1 more source

Towards the Discovery of Influencers to Follow in Micro-Blogs (Twitter) by Detecting Topics in Posted Messages (Tweets)

open access: yesApplied Sciences, 2020
Micro-blogs, such as Twitter, have become important tools to share opinions and information among users. Messages concerning any topic are daily posted. A message posted by a given user reaches all the users that decided to follow her/him.
Mubashir Ali   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Precision testing method of five-axis NC machine tool based on ‘S’ specimen cutting

open access: yesThe Journal of Engineering, 2019
‘S’ specimen through its unique profile features makes it possible to fully mobilise the five-axis linkage function in the five-axis finishing stage. The continuous rotation direction of the rotating axis not only reflects the static error of the machine
Mengying Xu, Hongjun Wang
doaj   +1 more source

Usability evaluation model of an application with emphasis on collaborative security: an approach from social dimensions

open access: yesJournal of the Brazilian Computer Society, 2021
Technological ubiquity and advances in the use of networked devices, such as smartphones, have become a fundamental element in the dynamics of information in the social environment.
Mateus de Oliveira   +2 more
doaj   +1 more source

Integrated computational product and production engineering for multi-material lightweight structures [PDF]

open access: yesThe International Journal of Advanced Manufacturing Technology, 2020
AbstractWithin product development processes, computational models are used with increasing frequency. However, the use of those methods is often restricted to the area of focus, where product design, manufacturing process, and process chain simulations are regarded independently.
Hürkamp, André   +8 more
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Optimisation estimation of uncertainty integrated with production information based on Bayesian fusion method

open access: yesThe Journal of Engineering, 2019
The new generation Geometrical Product Specifications require consideration of the effects of measurement uncertainty in the product inspection. This study estimated the measurement results and the uncertainty by integrating the statistical production ...
Yinbao Cheng   +5 more
doaj   +1 more source

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