Results 51 to 60 of about 5,010,518 (294)

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Data production models for the CDF experiment [PDF]

, 2006
The data production for the CDF experiment is conducted on a large Linux PC farm designed to meet the needs of data collection at a maximum rate of 40 MByte/sec.
Antos, J., Babik, M., Benjamin, D., Cabrera, S., Chan, A. W., Chen, Y. C., Coca, M., Cooper, B., Genser, K., Hatakeyama, K., Hou, S., Hsieh, T. L., Jayatilaka, B., Kraan, A. C., Lysak, R., Mandrichenko, I. V., Robson, A., Siket, M., Stelzer, B., Syu, J., Teng, P. K., Timm, S. C., Tomura, T., Vataga, E., Wolbers, S. A., Yeh, P.   +25 more
core   +2 more sources

Designing and implementation of an intelligent manufacturing system

Journal of Industrial Engineering and Management, 2011
Purpose: The goal of XPRESS is to establish a breakthrough for the factory of the future with a new flexible production concept based on the generic idea of “specialized intelligent process units” (“Manufactrons”) integrated in cross-sectoral learning ...
Michael Peschl, Norbert Link, Michael Hoffmeister, Gil Gonçalves, Fernando L. F. Almeida   +4 more
doaj   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

EXPERT expands prime editing efficiency and range of large fragment edits

Nature Communications
Prime editing systems (PEs) hold great promise in modern biotechnology. However, their editing range is limited as PEs can only modify the downstream sequences of the pegRNA nick.
Youcai Xiong, Yinyu Su, Ruigao He, Xiaosong Han, Sheng Li, Minghuan Liu, Xiaoning Xi, Zijia Liu, Heng Wang, Shengsong Xie, Xuewen Xu, Kui Li, Jifeng Zhang, Jie Xu, Xinyun Li, Shuhong Zhao, Jinxue Ruan   +16 more
doaj   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Improved modelling of helium and tritium production for spallation targets [PDF]

, 2009
Reliable predictions of light charged particle production in spallation reactions are important to correctly assess gas production in spallation targets.
A. Boudard, A. Kelić-Heil, Agostini, Alard, Ammon, Bertini, Bertrand, Bogatin, Boudard, Boudard, Broders, Currie, D. Mancusi, Enke, Fireman, Guertin, Hendricks, Herbach, Hilscher, J. Cugnon, J.C. David, Junghans, Le Gentil, Leray, Letourneau, Leya, M.V. Ricciardi, Mashnik, Mashnik, Natowitz, S. Leray, Yariv   +31 more
core   +1 more source

Linking population dynamics models with empirically derived models through phytoplankton primary production

Ecology and Evolution, 2021
There are alternative methods for estimation of phytoplankton primary production (PP) that are fundamentally different in the calculation approach. The process‐oriented PP model is a mechanistic, empirically derived method based on the photosynthesis ...
Motomi Genkai‐Kato
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source