Results 61 to 70 of about 31,459,926 (308)

EXPERT expands prime editing efficiency and range of large fragment edits

open access: yesNature Communications
Prime editing systems (PEs) hold great promise in modern biotechnology. However, their editing range is limited as PEs can only modify the downstream sequences of the pegRNA nick.
Youcai Xiong   +16 more
doaj   +1 more source

Designing and implementation of an intelligent manufacturing system

open access: yesJournal of Industrial Engineering and Management, 2011
Purpose: The goal of XPRESS is to establish a breakthrough for the factory of the future with a new flexible production concept based on the generic idea of “specialized intelligent process units” (“Manufactrons”) integrated in cross-sectoral learning ...
Michael Peschl   +4 more
doaj   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita   +5 more
wiley   +1 more source

Linking population dynamics models with empirically derived models through phytoplankton primary production

open access: yesEcology and Evolution, 2021
There are alternative methods for estimation of phytoplankton primary production (PP) that are fundamentally different in the calculation approach. The process‐oriented PP model is a mechanistic, empirically derived method based on the photosynthesis ...
Motomi Genkai‐Kato
doaj   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte   +5 more
wiley   +1 more source

Regression Models for Lean Production [PDF]

open access: yes, 2017
Data mining models are an excellent tool to help companies that live from the sales of items they produce because it allows the company to optimize its production and reduce costs, for example in storage. When these models are combined with Lean Production, it becomes easier to remove waste and optimize industrial production.
Ricardo Bragança   +2 more
openaire   +2 more sources

Ironic Medications: A Narrative‐Based Psycho‐Educational Intervention to Explore Patient–Provider Communication in Adolescents With Haematological Cancer

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with haematological malignancies face significant emotional and relational challenges, often accompanied by difficulties in communicating their needs within the healthcare context. To address these issues, a narrative‐based psycho‐educational intervention based on the creation and prescription of Ironic Medications was ...
Marta Stoppa   +7 more
wiley   +1 more source

The Linked Dual Representation model of vocal perception and production

open access: yesFrontiers in Psychology, 2013
The voice is one of the most important media for communication, yet there is a wide range of abilities in both the perception and production of the voice.
Sean eHutchins   +2 more
doaj   +1 more source

Incidence and Severity of Carboplatin‐Associated Hearing Loss in Children With Cancer Assessed by the SIOP Boston 2012 Ototoxicity Criteria

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Platinum‐based chemotherapy is known to cause severe and debilitating hearing loss, but unlike cisplatin, the true incidence of carboplatin‐induced hearing loss remains unclear. We evaluated functional hearing outcomes in children receiving carboplatin to determine the incidence and severity of ototoxicity. Procedure We identified a
Aniket Chawla   +6 more
wiley   +1 more source

Application of simulation models based on the theory of constraints in production

open access: yesRevista CEA, 2017
The Theory of Constraints enables to identify difficulties, called bottlenecks, in production processes. It seeks to find an optimal solution from a thorough and systematic perspective to achieve the business objective, generating profit.
Julián Alberto Uribe-Gómez   +1 more
doaj   +1 more source

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