Results 131 to 140 of about 16,758,400 (349)

Beyond Technical Skills: Competency Framework for Engineers in the Digital Transformation Era

Societies
In the context of digital transformation and Industry 4.0, the engineering profession is evolving rapidly, demanding new skill sets to maintain employability and support career development. This study identifies the competencies engineers must acquire to
Nádya Zanin Muzulon, Luis Mauricio Resende, Gislaine Camila Lapasini Leal, Joseane Pontes   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Healthcare can’t stop evolving: innovation as the catalyst for unleashing the managerial potential of value-based healthcare by stimulating intangible assets and enhancing organizational resilience

Frontiers in Psychology
BackgroundWith increasing healthcare service utilization and the introduction of costly therapies, healthcare organizations are pressured to deliver cost-effective services within constrained budgets.
João Francisco Pollo Gaspary, Vinícius Jaques Gerhardt, Claudia de Freitas Michelin, Luis Felipe Dias Lopes, Carmen Brum Rosa, Julio Cezar Mairesse Siluk   +5 more
doaj   +1 more source

The Determining Factors of Entrepreneurial Activity in Broiler Farms [PDF]

, 2013
Indonesia still requires approximately 4 million entrepreneurs to become a developed country. This research aimed at identifying and analyzing the factors forming the broiler farm entrepreneurial activities that contribute on generating new entrepreneurs
Burhanuddin, B. (Burhanuddin), Harianto, H. (Harianto), Nurmalina, R. (R), Pambudy, R. (R)   +3 more
core  

Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Nature Cell Biology, 2023
Sanjay Jain, Liming Pei, J. Spraggins, Michael Angelo, J. Carson, Nils Gehlenborg, F. Ginty, Joana P. Gonçalves, Jim Hagood, J. Hickey, N. Kelleher, L. Laurent, Shin Lin, Yiing Lin, Huiping Liu, A. Naba, E. Nakayasu, W. Qian, Andrea J. Radtke, P. Robson, B. Stockwell, R. Van de Plas, I. Vlachos, Mowei Zhou, Katy Börner, M. Snyder   +25 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Monitoring Brazilian Food Security Based on Emergy Concepts: A Proposed Approach

Resources
This study enhances the discussion on food security by examining trade equity between food consumers and the supply chain from an emergy perspective.
Rafael Araujo Nacimento, Mario Duarte Canever, Luiz Carlos Terra dos Santos, Cecília Almeida, Feni Agostinho, Biagio Fernando Giannetti   +5 more
doaj   +1 more source

Heuristic Solutions for Loading in Flexible Manufacturing Systems [PDF]

, 1996
Production planning in flexible manufacturing system deals with the efficient organization of the production resources in order to meet a given production schedule. It is a complex problem and typically leads to several hierarchical subproblems that need
Chen, Wun-Hwa, Srivastava, Bharatendu
core   +1 more source