Results 121 to 130 of about 4,393,221 (308)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Model Development for Identifying Aromatic Herbs Using Object Detection Algorithm

AgriEngineering
The rapid evolution of digital technology and the increasing integration of artificial intelligence in agriculture have paved the way for groundbreaking solutions in plant identification.
Samira Nascimento Antunes, Marcelo Tsuguio Okano, Irenilza de Alencar Nääs, William Aparecido Celestino Lopes, Fernanda Pereira Leite Aguiar, Oduvaldo Vendrametto, João Carlos Lopes Fernandes, Marcelo Eloy Fernandes   +7 more
doaj   +1 more source

PRICE ENHANCEMENT, RETURNS VARIABILITY, AND SUPPLY RESPONSE IN THE U.S. DAIRY SECTOR [PDF]

Dairy producers operating in the U.S. have been protected against market price variability by the federal price support program for over 35 years. During the late 1970s tax outlays to operate this program grew at a rapid rate.
Hammond, Jerome W., Thraen, Cameron S.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Beyond Technical Skills: Competency Framework for Engineers in the Digital Transformation Era

Societies
In the context of digital transformation and Industry 4.0, the engineering profession is evolving rapidly, demanding new skill sets to maintain employability and support career development. This study identifies the competencies engineers must acquire to
Nádya Zanin Muzulon, Luis Mauricio Resende, Gislaine Camila Lapasini Leal, Joseane Pontes   +3 more
doaj   +1 more source

Sunflower Variety Trial [PDF]

, 2013
Sunflowers are being grown in the Northeast for their potential to add value to a diversified operation as fuel, feed, fertilizer, and an important rotational crop. The major sunflower production areas are in the northern Great Plains, so seed production
Burke, Conner, Cummings, Erica, Darby, Heather, Harwood, Hannah, Monahan, Susan   +4 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

NASA/GE quiet engine C acoustic test results [PDF]

The acoustic investigation and evaluation of the C propulsion turbofan engine are discussed. The engine was built as a part of the Quiet Engine Program.
Kazin, S. B., Pass, J. E.
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

PRODUCTION AND PROFITABILITY RESPONSES TO ALTERNATIVE PROTEIN SOURCES IN BROILER RATIONS [PDF]

Profitability of using peanut meal as an alternative protein source in broiler production was investigated through the development of a two-stage mathematical program that optimizes broiler production.
Costa, Ecio de Farias, Houston, Jack E., Miller, Bill R., Pesti, Gene M.   +3 more
core   +1 more source