Results 131 to 140 of about 4,393,221 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Healthcare can’t stop evolving: innovation as the catalyst for unleashing the managerial potential of value-based healthcare by stimulating intangible assets and enhancing organizational resilience

Frontiers in Psychology
BackgroundWith increasing healthcare service utilization and the introduction of costly therapies, healthcare organizations are pressured to deliver cost-effective services within constrained budgets.
João Francisco Pollo Gaspary, Vinícius Jaques Gerhardt, Claudia de Freitas Michelin, Luis Felipe Dias Lopes, Carmen Brum Rosa, Julio Cezar Mairesse Siluk   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Monitoring Brazilian Food Security Based on Emergy Concepts: A Proposed Approach

Resources
This study enhances the discussion on food security by examining trade equity between food consumers and the supply chain from an emergy perspective.
Rafael Araujo Nacimento, Mario Duarte Canever, Luiz Carlos Terra dos Santos, Cecília Almeida, Feni Agostinho, Biagio Fernando Giannetti   +5 more
doaj   +1 more source

Analysis of spacecraft data [PDF]

A software program for the production and analysis of data from the Dynamics Explorer-A (DE-A) satellite was maintained and modified and new software initiated.

core   +1 more source

Heuristic Solutions for Loading in Flexible Manufacturing Systems [PDF]

, 1996
Production planning in flexible manufacturing system deals with the efficient organization of the production resources in order to meet a given production schedule. It is a complex problem and typically leads to several hierarchical subproblems that need
Chen, Wun-Hwa, Srivastava, Bharatendu
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

AUTONOMOUS CT REPLACEMENT METHOD FOR THE SKULL PROSTHESIS MODELLING

Facta Universitatis. Series: Mechanical Engineering, 2015
The geometric modeling of prosthesis is a complex task from medical and engineering viewpoint. A method based on CT replacement is proposed in order to circumvent the related problems with the missing information to modeling.
Marcelo Rudek, Yohan Boneski Gumiel, Osiris Canciglieri Jr   +2 more
doaj  

Improvement in stands pricing and candidate companies allocation at agricultural exposition

Journal of the Saudi Society of Agricultural Sciences
Agricultural expositions are events aimed at product sales, training, technology dissemination, and integration between the agricultural sector and urban residents.
Ronier Gutierrez, Alvaro Neuenfeldt Júnior, Matheus Francescatto, Milton Mandlhate, Sabine De Paris   +4 more
doaj   +1 more source