Results 101 to 110 of about 4,393,221 (308)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Experimental analysis of airwave propagation and attenuation in railway track hardening using explosives

Discover Civil Engineering
The study of airwave propagation and attenuation arising from explosive hardening of railway crossings is of paramount importance for the dual objective of safeguarding surrounding infrastructure and ensuring compliance with increasingly stringent ...
Raúl Rodríguez de la Fuente, Manuel Castejón Limas, Javier Alfonso Cendón, Gabriel Medina Martínez   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Structuring Corporate Governance in the Context of Crisis: Lessons from the COVID-19 Pandemic in a Nonprofit Organization

Administrative Sciences
This study aimed to analyze the adaptations in the corporate governance practices of a Brazilian support foundation, in the context of the crisis caused by the COVID-19 pandemic.
Raffaella Regueira de Oliveira, Osvaldo Luiz Gonçalves Quelhas, Níssia Carvalho Rosa Bergiante   +2 more
doaj   +1 more source

Effect of Heating and Soaking Time with KNO3 on Breaking Dormancy of Oil Palm Seeds (Elaeis guineensis Jacq.) [PDF]

BIO Web of Conferences
Oil palm (Elaeis guineensis Jacq.) is one of the plants that has a long dormancy period for germination because it has a thick and hard shell. Breaking dormancy is needed for seed production, so that it can accelerate the process of oil palm germination.
Zuanda Hasibuan Azhar, Adistya Putri Halida, Natalia Purba Fransiska   +2 more
doaj   +1 more source

Customizable Area Whole Farm Insurance (CAWFI) [PDF]

The customizable area whole farm insurance (CAWFI) was designed and compared with no insurance program and currently available whole farm insurance based on farm level yield (CFWFI). The CAWFI yields higher certainty equivalents over no insurance program,
Barnett, Barry J., Chalise, Lekhnath, Coble, Keith H.   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Smart Postharvest Management of Strawberries: YOLOv8-Driven Detection of Defects, Diseases, and Maturity

AgriEngineering
Strawberries are highly perishable fruits prone to postharvest losses due to defects, diseases, and uneven ripening. This study proposes a deep learning-based approach for automated quality assessment using the YOLOv8n object detection model.
Luana dos Santos Cordeiro, Irenilza de Alencar Nääs, Marcelo Tsuguio Okano   +2 more
doaj   +1 more source

Recent LHCb Results

, 2011
The LHCb experiment started its physics program with the 37/pb of pp collisions at 7 TeV c.m. energy delivered by the LHC during 2010. The performances and capability of the experiment, conceived for precision measurements in the heavy flavour sector ...
Graziani, Giacomo
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source