Results 71 to 80 of about 11,185,446 (211)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Economic Evaluation of Pest Management Technologies for Sustainable Cotton Production in Punjab [PDF]

This study has been undertaken to make cotton production in the state of Punjab globally competitive by reducing the cost of production at farmer’s level through adoption of new pest management technologies, namely Integrated Pest Management (IPM) and ...
Singh, Sukhpal, Singh, Satwinder
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Adoption Scale Analysis of Improved Cocoyam Production, Production and Storage Technologies across Gender in Enugu North Agricultural Zone of Enugu State Nigeria [PDF]

This study was undertaken to determine the adoption of improved cocoyam production, processing and storage technologies among small-holder cocoyam farmers in Enugu-North Agricultural Zone in Enugu state.
Amaefula, A.B, Dimelu, M.U, Agbaeze, C.C, Okoye, B.C, Okoroafor, O.N, Okoye, A.C   +5 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Production Efficiency and Agricultural Technologies in the Ethiopian Agriculture [PDF]

Stochastic frontier production function analysis was performed to examine relative crop and milk production efficiency among peasants in Ada and Selale districts of the Central highlands of Ethiopia.
Mariam, Yohannes, Coffin, Garth
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Impacts of Reproductive Technologies on Beef Production in South America

, 2014
The majority of beef cow herds in South America are constituted by Bos indicus females, which have particular reproductive features that contribute to reduced reproductive efficiency compared with that of B. taurus cohorts. Hence, several alternatives to
DiLorenzo, N., Vasconcelos, José Luiz Moraes, Cooke, Reinaldo Fernandes [UNESP], Lamb, G. C., Vasconcelos, José Luiz Moraes [UNESP], Cooke, Reinaldo Fernandes, Sa Filho, Ocilon Gomes de [UNESP], Sa Filho, Ocilon Gomes de   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source