Results 51 to 60 of about 285,950 (266)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Economic weights of production and functional traits in dairy cattle under a direct subsidy regime

Czech Journal of Animal Science, 2009
: Economic weights (EW) for the Slovak dairy production system were calculated in Holstein, Slovak Simmental, and Slovak Pinzgau breeds under a direct support regime using a bio-economic approach.
Z. Krupová, J. Huba, J. Daňo, E. Krupa, M. Oravcová, D. Peškovičová   +5 more
doaj   +1 more source

Determination of economic selection index coefficients for dairy cows [PDF]

Ekonomika Poljoprivrede (1979), 2014
There is no research regarding economic effects of genetic improvement for dairy cattle in Serbia. Therefore, the goal of this paper is to determine economic values for various production traits (milk yield, milk fat content and proteins content) in ...
Ivanović Sanjin, Stanojević Dragan, Nastić Lana, Jeločnik Marko   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of DGAT1 gene variants on milk quantity and quality in Holstein, Simmental and Brown Swiss cattle breeds in Croatia

Mljekarstvo, 2015
The aim of this study was to determine allele frequency at the diacylglycerol-O-transferase 1 gene (DGAT1) K232A polymorphic site and effect of allelic variants K and A on milk production traits of Holstein (dairy), Simmental and Brown Swiss (dual ...
Admir Dokso, Ante Ivanković, Ervin Zečević , Muhamed Brka   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Overlapping chromosomal regions for fertility traits and production traits in the Danish Holstein population [PDF]

Journal of Dairy Science, 2009
Before implementing selection based on quantitative trait loci (QTL) for fertility, it is important to determine the existence of correlated effects between the fertility QTL and QTL with effects on production traits. When a QTL is detected for a trait that is a composite of subtraits, it is of interest to validate which of the subtraits are affected ...
Höglund, Johanna Karolina, Buitenhuis, A J; id_orcid 0000-0002-4953-3081, Guldbrandtsen, B, Su, G, Thomsen, B; id_orcid 0000-0001-9622-0929, Lund, M S; id_orcid 0000-0001-5327-0897   +5 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Application of reproductive technologies to the improvement of dairy cattle genomic selection

Вавиловский журнал генетики и селекции, 2015
Genomic selection is a direction of breeding in which the value of an animal is predicted from DNA markers evenly covering the entire genome. This review summarizes information on modern trends in the genomic selection of dairy cattle and on application ...
N. S. Yudin, K. I. Lukyanov, M. I. Voevoda, N. A. Kolchanov   +3 more
doaj   +1 more source