Results 101 to 110 of about 1,776,568 (282)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Kajian Termal Akibat Paparan Panas dan Perbaikan Lingkungan Kerja
Jurnal Teknik Industri, 2012 This study aims to analyze thermal condition and improve working environment by designed ventilation systems due to improve air circulation and reduce heat exposure occurred so that workers feel more comfortable working.
Listiani Nurul Huda +1 more
doaj
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Happy-Productive worker thesis: The role of work characteristics, gender, and age.
PLoS ONEHappy-productive worker thesis (HPWT) research predicts four configurations depending on well-being and performance levels, one synergistic and three antagonists; however, there has been some discrepancy in the expected results of HPWT, as there are some
Jaime A Bayona +6 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Volunteer Work, Informal Help, and Care among the 50+ in Europe: Further Evidence for 'Linked' Productive Activities at Older Ages [PDF]
Objectives - Taking a cross-national comparative perspective, we investigate linkages between volunteer work, informal helping, and caring among Europeans aged 50 or older: Is the relationship between these activities characterized by complementarity or ...
Karsten Hank, Stephanie Stuck
core
The effects of resources across school phases: a summary of recent evidence [PDF]
, 2013 This report provides an overview and discussion of the past decade of academic evidence on the causal effects of resources in schooling on students’ outcomes.
Gibbons, Stephen, McNally, Sandra
core +1 more source