Results 141 to 150 of about 2,178 (240)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Wildland-Urban Interface (WUI) Smoke Yields of Nonmethane Organic Gases from Combustion of Small-Scale Residential Building Surrogates. [PDF]

ACS EST Air
Link MF, Davis AY, Lima NM, Falkenstein-Smith RL, Bryant RA, Cleary TG, Poppendieck D.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

[Hypoglycemia in a patient with pleural solitary fibrous tumor and response to pasireotide] [PDF]

Rev Fac Cien Med Univ Nac Cordoba
Videla EK, Ferrada P, Miller J, Torres E, Álvarez A, Herrera J, De la Torre B.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

[Nutrition with a planetary health perspective: Strategies for Primary Health Care]. [PDF]

Aten Primaria
Bellido Izquierdo P, Royo Vidal M, Ramírez Arroyo V, Robles Díez E.   +3 more
europepmc   +1 more source

Dietary eating patterns, dairy consumption, and anxiety: A systematic literature review. [PDF]

PLoS One, 2023
Movva N, Reichert H, Hooda N, Bylsma LC, Mitchell M, Cohen SS.   +5 more
europepmc   +1 more source

"El productor de cine"

, 2002
El productor de cine se encuentra entre los "grandes olvidados" de la historia del séptimo arte. Su trabajo implica gran variedad de saberes y destrezas, tanto creativas como de gestión. Este artículo enumer las cualidades que todo buen productor debe poseer y describe los principales tipos de productores existentes hoy día en la industria ...
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Oral keratinocyte-mediated inflammation and epithelial disruption: A narrative review on IRF6 signaling and oral carcinogenic risk. [PDF]

Int J Immunopathol Pharmacol
Osorio-Osorno YA, Parada-Sanchez MT.
europepmc   +1 more source