Results 171 to 180 of about 274,514 (304)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

[Streptococcus pyogenes vulvovaginitis in adult women]. [PDF]

Rev Esp Quimioter
Amores-Antequera C, Delgado-Baena A, Parrado-Hernando P, Cantudo-Muñoz P, Velasco-Rodríguez L.   +4 more
europepmc   +1 more source

Economic distress and discourse : the rise of a corporatist rhetoric in Northern Spain after World War I [PDF]

The paper explores the relationship between language and economy, between text and context, through a case study: the Basque region in northern Spain during World War I and the immediate postwar years.
Juan Carlos Rojo Cagigal
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

General corruption scale: development and psychometric properties. [PDF]

BMC Psychol
Modesto JG, Pilati R, Ferraz AS, Sarmet MM, Resende MM, Porto JB, Pereira CR.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The triple cost of tobacco and sugary drinks: health, economy and the environment. [PDF]

Rev Peru Med Exp Salud Publica
Alcaraz A, Espinola N.
europepmc   +1 more source

Tumores productores de inmunoglobulinas

Immunoglobulín-producing tumors in the dog are usually associated with lymphoproliferatiue disorders. The multiple myeloma is the most common and it is the more frequent cause of a monoclonal gammapathy. This tumor has a very low incidence and the diagnosis is quite difficult. The clínical signs sometimes are vague and non specific.
Font Utset, Artur, Durall Rivas, Ignacio, Closa, Josep Maria, Mascort Boixeda, Joan   +3 more
openaire   +1 more source

Estrategias económicas de pequeños productores

, 2003
El trabajo se desarrolló en el Departamento 9 de Julio de la Provincia del Chaco, en la República Argentina; con la finalidad de identificar las estrategias económicas adoptadas por los pequeños productores y la caracterización de las variables intervinientes, planteando supuestos respecto a estrategias y dotación de recursos.
Paredes, Hilda G., Macarrein, Omar Faustino   +1 more
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source