Results 61 to 70 of about 190,558 (333)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Some products of subgroups and vanishing conjugacy class sizes [PDF]

open access: yes, 2023
In this note, we investigate some products of subgroups and vanishing conjugacy class sizes of finite groups. We prove some supersolubility criteria for groups with restrictions on the vanishing conjugacy class sizes of their subgroups.https://www ...
Pedraza-Aguilera, Maria C.   +3 more
core   +1 more source

On the factorised subgroups of products of cyclic and non-cyclic finite $p$-groups

open access: yesComptes Rendus. Mathématique
Let $p$ be an odd prime and let $ G = AB $ be a finite $p$-group that is the product of a cyclic subgroup $A$ and a non-cyclic subgroup $B$. Suppose in addition that the nilpotency class of $B$ is less than $\frac{p}{2}$.
McCann, Brendan
doaj   +1 more source

Smokers’ strategies to reduce tobacco spending: self-reported use and differences across subgroups. Findings from the International Tobacco Control (ITC) Netherlands Survey

open access: yesBMC Public Health, 2023
Background The cost of tobacco is one of the most reported reasons for smoking cessation. Rather than quitting, smokers can use also strategies to reduce tobacco expenditure while continuing smoking, such as smoking less or using price-minimising ...
Cloé Geboers   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Graph products of groups [PDF]

open access: yes, 1990
In the 1970's Baudisch introduced the idea of the semifree group, that is, a group in which the only relators are commutators of generators. Baudisch was mainly concerned with subgroup problems, employing length arguments on the elements of these groups.
Green, E.R, Green, Elisabeth Ruth
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Hereditary conjugacy separability of right angled Artin groups and its applications

open access: yes, 2012
We prove that finite index subgroups of right angled Artin groups are conjugacy separable. We then apply this result to establish various properties of other classes of groups.
Minasyan, Ashot
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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