Results 71 to 80 of about 390,832 (276)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Women’s gambling behaviour, product preferences, and perceptions of product harm: differences by age and gambling risk status

Harm Reduction Journal, 2018
Background Women’s participation in, and harm from gambling, is steadily increasing. There has been very limited research to investigate how gambling behaviour, product preferences, and perceptions of gambling harm may vary across subgroups of women ...
Simone McCarthy, Samantha L. Thomas, Melanie Randle, Amy Bestman, Hannah Pitt, Sean Cowlishaw, Mike Daube   +6 more
doaj   +1 more source

Subdirect products of groups and the n-(n+1)-(n+2) Conjecture [PDF]

, 2013
We analyse the subgroup structure of direct products of groups. Earlier work on this topic has revealed that higher finiteness properties play a crucial role in determining which groups appear as subgroups of direct products of free groups or limit ...
Kuckuck, Benno
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Prevalence, Characteristics, and Selection of Bacillus cereus Subgroups from Dairy Products for Challenge Testing and Predictive Model Development

Journal of Food Protection
Prevalence, toxin gene profiles, lactose fermentation, and growth responses of B. cereus sensu lato subgroups in various dairy and dairy alternative products and ingredients were studied to identify relevant isolates for challenge testing and model ...
Maryam Maktabdar, Lisbeth Truelstrup Hansen, Ellen Wemmenhove, Elissavet Gkogka, Paw Dalgaard   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Some classes of minimally almost periodic topological groups

Applied General Topology, 2015
A Hausdorff topological group G=(G,T) has the small subgroup generating property (briefly: has the SSGP property, or is an SSGP group) if for each neighborhood U of $1_G$ there is a family $\sH$ of subgroups of $G$ such that $\bigcup\sH\subseteq U$ and $\
Wistar Comfort, Franklin R. Gould
doaj   +1 more source

Permutable subgroups of a direct product

Journal of Algebra, 2003
A subgroup \(S\) of a group \(G\) that permutes with each subgroup of \(G\) is said to be `permutable' (quasinormal). The author continues his investigations on characterizing permutable subgroups of a direct product \(G\times H\) of finite groups which reduces to the case that \(G\times H\) is a \(p\)-group, the focus for this article.
openaire   +2 more sources