Results 61 to 70 of about 1,995 (175)

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium Tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 42 homoisoflavones were synthesized and evaluated against Mycobacterium tuberculosis (Mtb). Three derivatives showed potent inhibition of Mtb strains. Evaluation in infected macrophages revealed promising intracellular activity, where one derivative featuring a nitrofuranyl and piperidine group emerges as the most promising.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle F. Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

Electrochemistry and Antioxidant Activities of Substituted Furanyl Nitrone: The Role of the Nitro Group

ChemElectroChem, Volume 12, Issue 13, July 3, 2025.
N‐methyl‐nitroaryl‐furanyl‐nitrone (LQB‐569) suffers a 10‐electron reduction, forming a hydrazine group with two terminal hydroxylamine groups. Nitrones’ antioxidant capacity (AO), despite being very low, correlates with their oxidation profiles, and the ones able to oxidize more easily have better results on DPPH• scavenging and ferric‐reducing ...
Danyelle Cândido Santos, Débora de Souza dos Santos Costa, Paulo R. R. Costa, Ayres Guimarães Dias, Messias de Oliveira Silva, Taualia Achira Aly, Vinícius Del Colle, Jadriane Almeida Xavier, Marília O. F. Goulart, Thaissa Lúcio Silva   +9 more
wiley   +1 more source

Avaliação do potencial antipsoriático de formulações tópicas contendo frações de Lacistema pubescens Mart.: um estudo in vivo

HU Revista
Introdução: A psoríase, uma doença inflamatória crônica e imunomediada da pele, afeta aproximadamente 125 milhões de pessoas no mundo. Agentes imunossupressores são geralmente utilizados, porém podem causar efeitos colaterais locais e sistêmicos.
Josiane Mello da Silva, Nícolas de Castro Campos Pinto, Renata de Freitas Mendes, Maria Christina Marques Nogueira Castañon, Elita Scio   +4 more
doaj   +1 more source

Mechanisms Underlying Vasorelaxation Induced in Rat Aorta by Galetin 3,6-Dimethyl Ether, a Flavonoid from Piptadenia stipulacea (Benth.) Ducke

Molecules, 2014
In this study, we investigated the relaxant action of galetin 3,6-dimethyl ether (FGAL) on rat aorta. The flavonoid relaxed both PMA‑ and phenylephrine (Phe)-induced contractions (pD2 = 5.36 ± 0.11 and 4.17 ± 0.10, respectively), suggesting the ...
Cibério L. Macêdo, Luiz H. C. Vasconcelos, Ana C. de C. Correia, Italo R. R. Martins, Daysianne P. de Lira, Bárbara V. de O. Santos, Fabiana de A. Cavalcante, Bagnólia A. da Silva   +7 more
doaj   +1 more source

Synthesis of biofuel esters catalyzed by lipase B from Candida antarctica immobilized on a magnetic lignin‐based support derived from cashew apple bagasse

Biofuels, Bioproducts and Biorefining, Volume 19, Issue 4, Page 1165-1173, July/August 2025.
Abstract This study investigated the biosynthesis of ethyl oleate (EO), the main constituent of biodiesel, via the esterification of oleic acid with ethanol, catalyzed by Candida antarctica lipase B (CALB) immobilized on a low‐cost support derived from cashew apple bagasse (CAB) lignin.
Hilldyson Moreira Levy, Tigressa Helena Soares Rodrigues, Tiago Lima de Albuquerque, Hosiberto Batista Sant’Ana, Filipe Xavier Feitosa, Maria Valderez Ponte Rocha   +5 more
wiley   +1 more source

Putatively Identified Sarmentoside-B Removes Oligomerized Amyloid Peptide from Neurons by Inhibiting mTOR and Restoring Lysosomal Function, in In Vitro Alzheimer’s Disease Model

Pharmaceutics
Background/Objectives: Alzheimer’s disease (AD) is characterized by beta-amyloid (Aβ) plaque deposition, which impairs several cellular processes, including autophagy.
Bruna Rojas Fróes, Juliana Guanaes Pina, Mariana da Mata Alves, Alquiandra S. F. Mançano, Fernanda C. Cardoso, Juliana Mozer Sciani   +5 more
doaj   +1 more source

Produtos naturais anti - Helicobacter pylori: revisão

Revista Ibero-Americana de Ciências Ambientais, 2018
A infecção pela bactéria Helicobacter pylori é considerada um problema de saúde pública, com intrínseca relação saúde e ambiente, a infecção bacteriana crônica mais comum no mundo, com alta prevalência em países em desenvolvimento. O uso de produtos naturais voltados a inovação medicamentosa, aumenta o interesse por novos princípios ativos a base de ...
Mariana Lenina Menezes Aleixo, Carla Galbiati, Larissa Maria Scalon Lemos   +2 more
openaire   +2 more sources

In Vitro and In Silico Evaluation of Isatin‐Derived Spirooxindoles as Antituberculosis Drug Candidates

Chemical Biology &Drug Design, Volume 106, Issue 1, July 2025.
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
Fernanda Rodrigues de Lima, Jéssika de Oliveira Viana, Aleff Cruz de Castro, Rodrigo Cristiano, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso, Claudio Gabriel Lima‐Junior, Valnês da Silva Rodrigues‐Junior, Karen Cacilda Weber   +11 more
wiley   +1 more source

Synthesis of Unnatural Amino Acids via β‐Aminoaldehyde C–H Arylation using HAT‐Metallaphotoredox Catalysis

Advanced Synthesis &Catalysis, Volume 367, Issue 9, May 6, 2025.
Abstract Unnatural amino acids play a crucial role in advancing protein engineering and drug development. In this study, we present the synthesis of a series of γ‐aryl‐keto‐α‐amino acids through the direct C−H arylation of readily accessible β‐aminoaldehydes and aryl bromides, promoted by hydrogen atom transfer combined with metallaphotoredox catalysis.
Mariana dos S. Dupim, Bruno M. da S. Santos, Lívia C. R. M. da Frota, Fernanda G. Finelli   +3 more
wiley   +1 more source

PEG‐400 Mediated N‐(Alkyl)Arylation for the Synthesis of Medicinally Relevant 4‐Aminoquinazolines

ChemistrySelect, Volume 10, Issue 15, April 17, 2025.
A new approach for quinazoline N‐(alkyl)arylation using PEG‐400 as a green solvent in microwave or conventional heating reactors presents an interesting option for synthesizing 4‐aminoquinazolines. This strategy is compatible with a variety of substituted amines and shows good tolerance for both electron‐donating and electron‐withdrawing groups, making
Gabriel de Paula Bueno, Luiz Vinícius Santos de Oliveira, Giovanna Preterotto Lourençon, Victor Hugo Catricala Fernandes, Leandro Alves Bozzini, Giuliano Cesar Clososki   +5 more
wiley   +1 more source