Results 171 to 180 of about 2,733,067 (295)

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

Advanced Science, EarlyView.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding, Zhongxiong Fan, Guoyu Xia, Fukai Zhu, Nan Yang, Shujie Yu, Longlong Yuan, Jinyao Li   +7 more
wiley   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Help-seeking behavior among college students with suicidal ideation: barriers, facilitators, and social actors. [PDF]

Psicol Reflex Crit
Cecchin HFG, Murta SG.
europepmc   +1 more source

An All‐Soft Wearable Electrochemiluminescence Chip for Sweat Metabolite Detection

Advanced Science, EarlyView.
A wearable electrochemiluminescence chip for sweat metabolite monitoring is pioneered, integrating “all‐soft” components: a flexible closed bipolar electrode (c‐BPE) array based on laser‐induced graphene (LIG), a laser‐cut microfluidic layer for sweat collection, and deep eutectic solvents (DES)‐based conductive ionogels for ECL emission.
Wei Nie, Jie Jiang, Xi Wei, Linfeng Zhuo, Danyang Li, Mingyu Jia, Tianhua Zheng, Hua Cui   +7 more
wiley   +1 more source

How to Tell a Recovery Story 'Professionally'? Issues Related to the Transformation of Personal Stories During a Training for Becoming a Peer Support Worker. [PDF]

Health Expect
Faccio E, Rocelli M, Salamina G, Aquili L.   +3 more
europepmc   +1 more source

FOCUS: A Four‐In‐One Consolidated Unison Strain Sensor with Enhanced Sensitivity

Advanced Science, EarlyView.
Through a folding transformation that stacks four printed liquid metal sensors into a unified 3D orthogonal construct, FOCUS harnesses complementary bidirectional resistance responses within a Wheatstone bridge. This architecture yields fivefold sensitivity enhancement and 25 µm resolution, overcoming LM sensors’ micro‐strain limitations and enabling ...
Zimeng Wang, Ruiran Li, Bowen Yang, Zhuofei Peng, Muyang Jing, Yu Gu, Lixue Tang   +6 more
wiley   +1 more source

Assessment of the level of knowledge about first aid among Polish army soldiers. [PDF]

Front Public Health
Krenzel I, Narewska I.
europepmc   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Converting an Entire Course Into a Game by Implementing Gated Pathways. [PDF]

Clin Teach
Sharmin N, Chow AK.
europepmc   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source