Results 81 to 90 of about 1,090,283 (308)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Calidad Microbiológica Del Agua Y Riesgo Sanitario De Dos Acueductos Rurales En El Estado Vargas, Venezuela Instrucctional Design In A Computarized Educational Material (Mec): The Pedagogical Platform Sivi 1.0

Investigación y Postgrado, 2005
El evento hidrometeorológico de 1999 colapsó el suministro de agua potable del Estado Vargas, y esta situación condujo a los habitantes de los centros poblados asentados en las cuencas bajas de los ríos Osorio y Piedra Azul, a una dependencia total de ...
Yolanda Barrientos, Carlos Suárez, Henry Pacheco, Simón Ruiz, Belkys Devia, Ysley Perdomo   +5 more
doaj  

Professional orientation in USFEU: current status and prospects [PDF]

, 2017
Выбор профессии является важной задачей, в решении которой заинтересованы и человек и государство. В связи с этим сотрудники УГЛТУ постоянно развивают новые формы профессиональной ориентации.The choice of profession is an important task in which ...
Помазуева, Т. Н.
core  

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

PROFESSIONAL ORIENTATION AND TYPE OF DESCRIPTION AS BARNUM EFFECT DETERMINANTS

Вестник Кемеровского государственного университета, 2013
Barnum effect determinants such as professional orientation and type of description (trivial, present and extraneous) were investigated. Two groups of students with professional socionomic and technical directions were interviewed.
V. V. Kalita, A. S. Gaiday
doaj  

Social and professional orientation of students in Russia [PDF]

, 2012
У статті аналізується російський досвід соціально-професійної орієнтації учнів, теоретичні основи їхньої гармонізації та засади формування особистісної характеристики - «компетентність» у процесі суб’єкт-суб’єктної взаємодії між учасниками навчально ...
Піддячий, Микола Іванович
core  

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

SPECIFICS OF PROFESSIONAL VOCABULARY OF PEDAGOGICAL ORIENTATION

Записки з романо-германської філології, 2018
The article deals with the questions about the study and systematization of terminology vocabulary of pedagogical orientation. The features of the professional vocabulary of a teacher are described.
К. О. Мулик
doaj   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Graduate Student Orientation through a Professional Seminar

Journal of College Orientation, Transition, and Retention, 2001
Traditional new student orientation programming is focused on the duality of academic preparation and social integration. For graduate students, especially doctoral students, much of the academic preparation has already been accounted for and social ...
Michael T. Miller, Albert S. Miles, Beverly G. Dyer   +2 more
doaj   +1 more source