Results 221 to 230 of about 2,712,008 (296)

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Information bubble and skill evolution: a theoretical framework for integrating distributed cognition, cognition offloading, and metacognitive regulation based on AIOE. [PDF]

Front Artif Intell
Lu T, Cheng Z.
europepmc   +1 more source

A Dual‐Delivery System Designed to Overcome EV‐Mediated Ferroptosis Resistance for Efficient Solid Tumor Therapy

Advanced Science, EarlyView.
(A) Establishment and characterization of the osteosarcoma‐targeted dual‐delivery nanoplatform mBAP1/siENO1@LNP‐OTP for simultaneous regulation of BAP1 and ENO1 in tumor cells. (B) After intravenous administration, mBAP1/siENO1@LNP‐OTP preferentially accumulates at tumor sites through OTP‐mediated targeting.
Yechao Shen, Zhenguo Cao, Zenan Wang, Liang Chen, Jiahao Zhang, Linjie Zeng, Boren Tan, Hengyuan Li, Jiashan Lai, Jiangchu Lei, Fanglu Chen, Peng Lin, Zhenxuan Shao, Zhan Wang   +13 more
wiley   +1 more source

Motivation and barriers to physicians' academic career in gastroenterology in France. [PDF]

Med Educ Online
Chouik Y, Sidali S, Canivet CM, Meunier L.   +3 more
europepmc   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Open Science in Undergraduate Medical Education: An International Framework for Transparency, Responsibility, and Professional Identity Formation. [PDF]

Perspect Med Educ
Jeung-Maarse H, Ecos RL, Jimenez-Soto LF, Linde P, Müssigmann M, Schuh S, Wahlster S, Yi CC.   +7 more
europepmc   +1 more source

A Biomimetic PLK1 Nanodelivery System Promotes Migrasome‐Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
MM‐NPs@PLK1 are formed by encapsulating PLK1 plasmids within CBP5 and coating the nanocomplexes with macrophage membranes. After macrophage‐associated uptake, the NPs@PLK1 enter the cytoplasm and release the PLK1‐encoding plasmid in response to elevated intracellular ROS levels.
Zhenxin Hu, Haoli Wang, Jing Huang, Junhua Zhou, Jialong Hou, Hanwei Miao, Huixin Tan, Yining Wang, Hao Hu, Na Li, Pengcheng Qiu, Hongyu Zhang, Da He, Qingqing Wang   +13 more
wiley   +1 more source

Construction of a nursing internship system through institutional collaboration: current status, challenges, and optimization pathways. [PDF]

Front Med (Lausanne)
Ren Y, Li C.
europepmc   +1 more source

An Epidermal Sweat Patch for Tracking Metabolite Levels and Correlation Analysis in Biofluids

Advanced Science, EarlyView.
This work presents an epidermal sweat patch for continuous glucose monitoring that validates a strong correlation between sweat, interstitial fluid and blood, enabling a reliable and non‐invasive platform for systemic health management. ABSTRACT Continuous, in situ monitoring of sweat biomarkers offers a promising approach for non‐invasive metabolic ...
Yao Chen, Xinhao Wan, Haoxin Fan, Hengwei Lou, Jialu Wang, Jie Gao, Dan Wen   +6 more
wiley   +1 more source

How Is Registered Nursing Time Used? A Multicentre Observational Study of Nursing Activities, Scope of Practice, and Opportunities for Workforce Redesign in Medical-Surgical Wards in Italy. [PDF]

Nurs Rep
Ivziku D, Vollero L, Alciati V, Ferramosca FMP, Cotichini V, Reato F, Lommi M, Tartaglini D.   +7 more
europepmc   +1 more source