Results 151 to 160 of about 926,824 (309)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
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علاج القبول والالتزام:1 assistant Professor associate Professor Professor associate Professor Professor

ينتمي علاج القبول والالتزام إلى "الموجة الثالثة" للعلاج السلوكي. ويقصد "بالموجة الثالثة" أن العلاج السلوكي يقترب هنا من الظواهر المعقدة جداً للسلوك الإنساني، التي كان من الصعب الوصول إليها حتى الآن من خلال مبادئ الإشراط الإجرائي ومفهوم التمثل الاستعرافي للمعلومات. ومن بين هذه الظواهر المعقدة الوعي، والقبول والقيم الشخصية والروحانية.
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Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Justify Your Alpha Assistant Professor Associate Professor Professor of Experimental Psychology Associate professor Assistant professor Assistant professor

In response to recommendations to redefine statistical significance to p ≤ .005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level.
Daniel Lakens, Federico G Adolfi, Casper Albers, Farid Anvari, Matthew A J Apps, Shlomo Engelson Argamon, Marcel A.L.M. van Assen, Thom Baguley, Raymond Becker, Stephen D. Benning   +9 more
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Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

الهجرة من منظور نفسي assistant Professor associate Professor Professor associate Professor Professor

تؤدي الهجرة إلى تغييرات كبيرة في البنية النفسية والاجتماعية لأي مجتمع كان؛ إنها تؤثر على الطبقات الاجتماعية والاقتصادية، والسياسة، والثقافية، والنظام الصحي. كما أنها تؤثر على إدراك المهاجرين والسكان المحليين على حد سواء، الأمر الذي يؤثر بدوره على الهجرة.
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Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

الاكتئاب لدى النساء Editor of ArabiXiv assistant Professor associate Professor Professor associate Professor Professor

يعد الاكتئاب، بمختلف أنواعه، من أكثر الاضطرابات النفسية انتشاراً وشدة، ومن أعراضه افتقاد المكتئبين لمعنى الحياة وتعكر مزاجهم والشعور باليأس والتعاسة والمعاناة والأرق وفقدان الأمل بالحياة من كل شيء، وقد ينتهي الاكتئاب بالانتحار في كثير من الحالات (15% وفقاً لبعض الدراسات والإحصائيات).
Khaled Moustafa, Samer Rudwan
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Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

الخوف الذي كشف الغطاء assistant Professor associate Professor Professor associate Professor Professor

في أزمة كورنا انكشف حجم الهشاشة التي نحن فيها. لقد ولد فيض المعلومات الكثيرة والمتناقضة وضعف الإمكانات الفردية للسيطرة على الخطر مشاعر التهديد، وظهرت بالنتيجة تصرفات قد تبدو غير مفهومة، كهوس شراء ورق التواليت والتخزين والمبالغة في تصرفات وظيفتها توليد الإحساس الوهمي للسيطرة على خطر يحمل صفة التهديد الحقيقي، وفي الوقت نفسه فإن الفرد لا يملك الكثير من ...
openaire   +1 more source