Results 261 to 270 of about 388,853 (307)

A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition

open access: yesAdvanced Science, EarlyView.
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li   +7 more
wiley   +1 more source

Enriched Soil Organic Carbon Underpins Long‐Term Stable Crop Productivity Across China's Croplands

open access: yesAdvanced Science, EarlyView.
Quantifying the nonlinear relationships and causal effects of soil organic carbon (SOC) on crop stability reveals specific critical thresholds and saturation points. This partitions the national SOC spectrum into three functional phases. Integrating these spatial delineations with high‐resolution maps of marginal gains pinpoints regions with the ...
Yuyang Huang   +11 more
wiley   +1 more source

Psychometric properties of the Incivility in Nursing Education - Revised Survey - Brazilian version. [PDF]

open access: yesRev Lat Am Enfermagem
Ribeiro VDS   +6 more
europepmc   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

open access: yesAdvanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang   +15 more
wiley   +1 more source

The Novel Viral Non‐Coding RNA LMP2A‐IT1 Promotes the Lytic Replication of EBV

open access: yesAdvanced Science, EarlyView.
Decades after its discovery, EBV's genome still harbours unannotated “dark matter”. LMP2A‐IT1, a novel EBV‐encoded transcript identified in this work, is strongly upregulated during lytic replication and promotes BZLF1 expression, likely through activation of inflammatory responses, thereby enhancing viral propagation in a self‐reinforcing positive ...
Zheng‐Zhou Lu   +15 more
wiley   +1 more source

Care strategies for children with tracheostomy at school: a scoping review. [PDF]

open access: yesRev Esc Enferm USP
Pessanha FB   +3 more
europepmc   +1 more source

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the Medial Prefrontal Cortex

open access: yesAdvanced Science, EarlyView.
This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li   +11 more
wiley   +1 more source

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