Results 281 to 290 of about 388,853 (307)

Mapping actions to promote physical activity in light of Health Promoting Schools. [PDF]

open access: yesRev Bras Enferm
Felício JF   +6 more
europepmc   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

open access: yesAdvanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen   +10 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang   +17 more
wiley   +1 more source

Mobile application for self-care in people with heart failure: a quasi-experimental study. [PDF]

open access: yesRev Esc Enferm USP
Santos WPD   +6 more
europepmc   +1 more source

Strain‐Enhanced Ultrastretchable Semiconducting Polymer Fibers for Organic Electrochemical Transistors

open access: yesAdvanced Science, EarlyView.
The continuous fabrication of stretchable polymer semiconductor p(g2T‐T) fibers is realized via wet‐spinning. The p(g2T‐T) semiconductor fibers possess an efficient strain energy dissipation mechanism and unique strain‐enhanced electrical performance. They can be stretched to over 250% strain and exhibit an ultrahigh normalized transconductance of 276 ...
Zixu Chang   +8 more
wiley   +1 more source

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