Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
THE IELTS READING TEST: A REVIEW ON ITS DEVELOPMENT AND LANGUAGE TEST PERFORMANCE
International English Language Testing System (IELTS) is regarded as one of proficiency tests that is generally accepted by British and Australian universities in selecting and screening overseas students.
Yuliar Masna
doaj +1 more source
Improving Proficiency in Central Venous Catheter Insertion: Standardized Simulation Based Training for Internal Medicine House Staff [PDF]
Objectives: The objectives of this study are to assess residents\u27 pre-workshop ability and comfort with CVC placement, undergo a standardized online didactic and hands-on clinical training simulation workshop, and subsequently undergo a proficiency ...
Hutchinson, MD, MA, Christoph +2 more
core +1 more source
Investigating examiner interventions in relation to the listening demands they make on candidates in oral interview tests [PDF]
Examiners intervene in second language oral interviews in order to elicit intended language functions, to probe a candidate’s proficiency level or to keep the interaction going.
Nakatsuhara, Fumiyo
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
[Results of the Proficiency Test for Diagnostic Testing of Notifiable Infectious Diseases]. [PDF]
Park OK, Lee SG, Park JS, Kim GJ.
europepmc +1 more source
Proficiency test SYKE 2/2013. Chlorophyll a, colour, conductivity, nutrients, pH and turbidity in natural waters [PDF]
Proftest SYKE carried out the proficiency test for analysis of chlorophyll, colour, conductivity, nutrients, pH and turbidity in natural waters in February 2013. In total 44 laboratories participated in this proficiency test.
Ilmakunnas, Markku +5 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Scoring validity of the Aptis Speaking test: investigating fluency across tasks and levels of proficiency [PDF]
Second language oral fluency has long been considered as an important construct in communicative language ability (e.g. de Jong et al, 2012) and many speaking tests are designed to measure fluency aspect(s) of candidates’ language (e.g. IELTS, TOEFL iBT,
Hunter, Ann-Marie +2 more
core
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source

