Results 121 to 130 of about 4,713,645 (328)
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
To profile or to marginalize - A SMEFT case study
SciPost PhysicsGlobal SMEFT analyses have become a key interpretation framework for LHC physics, quantifying how well a large set of kinematic measurements agrees with the Standard Model. This agreement is encoded in measured Wilson coefficients and their uncertainties.
Ilaria Brivio, Sebastian Bruggisser, Nina Elmer, Emma Geoffray, Michel Luchmann, Tilman Plehn
doaj +1 more source
A likelihood ratio test for stationarity of rating transitions [PDF]
For a time-continuous discrete-state Markov process as model for rating transitions, we study the time-stationarity by means of a likelihood ratio test. For multiple Markov process data from a multiplicative intensity model, maximum likelihood parameter ...
Walter, Ronja, Weißbach, Rafael
core
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
BMC Evolutionary Biology, 2004 Background In phylogenetic analysis we face the problem that several subclade topologies are known or easily inferred and well supported by bootstrap analysis, but basal branching patterns cannot be unambiguously estimated by the usual methods (maximum ...
Rahmann Sven +3 more
doaj +1 more source
Experimental scatter of the fatigue response of additively manufactured components: a statistical method based on the Profile Likelihood. [PDF]
Sci Rep, 2023 Tridello A +4 more
europepmc +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Classifying Job Value Profiles and Employment Outcomes Among Culinary Arts Graduates
SocietiesThe job values of college graduates are rapidly changing, but a mismatch between industry expectations and young chefs’ values has emerged. To capture the heterogeneity in job values that traditional variable-centered approaches may overlook, this study ...
Tae-Kyun Na, Saem Han
doaj +1 more source
Data in Brief, 2019 In the paper, “Probabilistic approaches to interpreting two-person DNA mixtures from post-coital specimens” [1], we analysed 102 two-person DNA samples from simulated mixtures and male-female and male-male post-coital specimens.
Jae Joseph Russell B. Rodriguez +4 more
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source