Results 61 to 70 of about 482,381 (267)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Spatial Tooth Profile Design and Optimization Analysis of Involute Harmonic Gear

Jixie chuandong, 2021
In order to improve the meshing performance of the involute tooth profile harmonic gear， the conjugate tooth profile discrete points in design section are obtained with an exact conjugate algorithm using assembly deformation of the flexspline，and the ...
Hongyan Wu, Xiaoxia Chen, Jingzhong Xing
doaj  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Research on thermal characteristics of gear based on parametric tooth profile modification

Advances in Mechanical Engineering
This paper establishes a thermal analysis model for parametric profile modification gears based on the heat transfer mechanisms of gear transmission. The main research parameters are the addendum coefficient and the modification coefficient, focusing on ...
Hengzhe Shi, Wei Li, Wanlin Zhou
doaj   +1 more source

A New Modification Method with Double Spline Curve for the Tooth Surface Design of Spur Gear

Jixie chuandong, 2021
A new tooth surface design is proposed to spur gears with a tooth surface modification defined by double spline curves， which are used to represent the tooth profile and longitudinal profile， respectively.
Wenjun Fan, Yuansheng Zhou, Xueqing Wang, Jinyuan Tang   +3 more
doaj  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Influence of Walker Curve Tooth Root Modification on Thermoelastic Grease Lubrication Characteristics of Large Internal Gears

Jixie chuandong, 2023
The influence of Walker curve modification method on the tooth surface lubrication state of grease lubricated large internal meshing cylindrical spur gears is studied. According to the meshing law and engineering experience of internal meshing gear pairs,
Wang Zhenbo, Zheng Peng, Zhao Wenhui
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source