Results 71 to 80 of about 497,791 (305)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Study and Application of Profile Modification in Offshore Fields

, 2010
This paper presents the findings from the study and application of profile modification in offshore fields and discusses how to select the proper agents and manage the operation for reservoirs with different geological characteristics ...
Yunxian Wang, Qinghong Yang, Ming Liu, Xinwu Liao, Chunming Zhao, Ruichang Yan   +5 more
core   +1 more source

Features of Design and Production of Planetary Gears in the Belarus Mobile Machines

Механика машин, механизмов и материалов, 2010
The basic requirements to the planetary transfers, used in heavy dumpers, lorries, tractors and other machines made in Belarus are formulated. Ways of improvement of quality and perfection of manufacture of planetary transfers are planned.
V.E. Antoniuk , P.L. Mariev , Pawlowski V.Ja.   +2 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reduction of gear pair transmission error with tooth profile modification

, 2008
The gear noise problem that widely occurs in power transmission systems is typically characterised by one or more high amplitude acoustic signals. The noise originates from the vibration of the gear pair system caused by transmission error excitation ...
Tharmakulasingam, R, Alfano, G, Atherton, MA   +2 more
core  

Influence of Tip Relief Profile Modification on Involute Spur Gear Stress

, 2016
This paper deals with the effects of linear tip profile modification on the stress of tooth root and tooth flank of involute spur gears. An increase in the tooth flank stress due to the tip profile modification is potentially hazardous because there is ...
Željko Vrcan, Marković, Kristina, Kristina Marković, Vrcan, Željko   +3 more
core   +1 more source

METHOD FOR MODIFYING PROFILE OF CYCLOIDAL WHEEL CONSIDERING COMPENSATION FOR ELASTIC DEFORMATION

Jixie qiangdu, 2020
Considering the influence of elastic deformation on the profile of the cycloid,a cycloid profile modification method for compensating elastic deformation is proposed.Based on the theory of cycloid profile modification,the coordinates of the meshing point
QIN ZhengZheng, WANG Quan, ZHAO DaXing, WANG Jun, ZENG LiLei   +4 more
doaj  

Mesh stiffness calculation of helical gears with profile modification

The Journal of Engineering, 2018
Time-varying contact line and mesh stiffness are important parameters for dynamic investigation of helical gear pair with profile modification; however, the calculation methods of the time-varying mesh with high accuracy and high efficiency are also very
Yu Wang, Yimin Shao, Zaigang Chen, Minggang Du, Huifang Xiao   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source