Results 91 to 100 of about 482,381 (267)

齿廓修形对齿轮齿面温度影响分析

open access: yesJixie chuandong, 2011
Parameterized mathematical modeling of gear is established and computation and analysis of the temperature of tooth surface are carried by ANSYS software.The profile modification of involute gear is introduced and the temperature of tooth surface after ...
杨龙, 李应生, 王志强, 汤鱼
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

PROFILE MODIFICATION INFLUENCE ON THE CONTACT RATIO FOR STRAIGHT BEVEL GEAR

open access: yesJournal of Industrial Design and Engineering Graphics, 2007
Bevel gear, as octoidal gear, is not accurate involute. As a result, unlike involute cylindrical gear, bevel gear is accomplished by using profile which are not modification or profile with zero modification.
VELICU Doru, MOLDOVEAN Gheorghe
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Methods Development for Protein and Modifications Profiling

open access: yes, 2021
Post-translational modifications (PTMs) occur in many forms, and broadly influence protein behavior. High-resolution tandem mass spectrometry coupled with engines for the identification of unspecified PTMs, is a first-choice method for their global mapping.
Smiljanić, Katarina   +5 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Method of Cycloid Gear Tooth Profile Modification of RV Reducer

open access: yesJixie chuandong, 2017
A kind of eccentricity combined modification method of cycloid gear profile is proposed for solving the problem of the common combination modification method could not simultaneously satisfy the requirements of high bearing capacity and low rotation ...
Zhang Fengshou   +3 more
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

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