Results 101 to 110 of about 482,381 (267)
Jixie qiangdu, 2015 For two branches of power transmission gear,the bending- torsion- shaft coupling dynamics model and the corresponding nonlinear dynamical equations are established in this paper,with considering the varying mesh stiffness,backlash and the tooth profile ...
DING RenLiang, WANG SanMin
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Precision Compensation Method of Tooth Profile in Form Grinding of Modified Helical Gears
Jixie chuandongThe coordinate equation of helical gear tooth profile modification and geometric algorithm of form grinding wheel dressing are established, and the section profile of grinding wheel after tooth profile modification is optimized.
Zhang Hao +3 more
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Jixie chuandong, 2010 Adopted high-order power function and short modification as the profile modification mode of spur gears used in astronomical telescopes,it can meet the necessity of the contact ratio and improve the static transmission error,and avoid stress ...
冯锦平, 马文礼
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Jixie chuandong, 2009 In the interest of improving cycloidal modification profile meshing quality, optimal value of modification equidistance and moved distance is optimized by optimization theory and approach the curve of normal gap of modification of rotated angle and ...
焦文瑞 +4 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Multi-objective Optimal Design of RV-550E Reducer Cycloid Gear Profile Modification
Jixie chuandong, 2018 In order to obtain the best overall performance of cycloid profile,a multi-objective optimal design method of cycloid gear profile modification is presented. The cycloidal gear tooth profile equation and modification theory are introduced.
Wang Quan +5 more
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