Results 121 to 130 of about 497,791 (305)

Study on Contact Force and Transmission Accuracy of Cycloidal Wheel with Exponential Modification

open access: yesJixie chuandong, 2020
RV reducer plays a dominant role in the field of robots because of its advantages of high accuracy,high efficiency and small size.Cycloid wheel,as the key component of RV reducer,directly affects the performance of the transmission system of RV reducer ...
Chen Xinwen, Zhu Min, Wang Qiliang
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Contact stresses in gear teeth due to tip relief profile modification

open access: yes, 2011
In this paper the linear tip relief profile modification has been observed. This kind of modification has been considered to be potentially dangerous considering micro-pitting initiation as a consequence of contact pressure increase.
Marina Franulović   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

齿廓修形对齿轮齿面温度影响分析

open access: yesJixie chuandong, 2011
Parameterized mathematical modeling of gear is established and computation and analysis of the temperature of tooth surface are carried by ANSYS software.The profile modification of involute gear is introduced and the temperature of tooth surface after ...
杨龙, 李应生, 王志强, 汤鱼
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Finite Element Analysis for Tooth Profile Modification of Gear-Box of Tracklayer

open access: yes, 2010
The quasi-static contact finite element analysis of meshing gear of gear-box is computed by using MSC.Marc software, then transmission error and surface contact stress of meshing gear are computed in different tooth profile modification methods.
Hui Yong Deng   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

S. symbiotica COG profile modification from FLS and between them.

open access: yes, 2012
S. symbiotica COG profile modification from FLS and between them.
Andrés Moya (2203084)   +3 more
core   +1 more source

Home - About - Disclaimer - Privacy