Results 121 to 130 of about 2,987,246 (293)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Jixie chuandongObjectiveTo achieve reasonable matching between the gear modification coefficient and tooth profile modification parameters and improve gear meshing performance, a meshing excitation calculation model for gear transmission systems considering both gear ...
CHEN Qingjian +3 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Jixie qiangdu, 2015 For two branches of power transmission gear,the bending- torsion- shaft coupling dynamics model and the corresponding nonlinear dynamical equations are established in this paper,with considering the varying mesh stiffness,backlash and the tooth profile ...
DING RenLiang, WANG SanMin
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Precision Compensation Method of Tooth Profile in Form Grinding of Modified Helical Gears
Jixie chuandongThe coordinate equation of helical gear tooth profile modification and geometric algorithm of form grinding wheel dressing are established, and the section profile of grinding wheel after tooth profile modification is optimized.
Zhang Hao +3 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Jixie chuandong, 2010 Adopted high-order power function and short modification as the profile modification mode of spur gears used in astronomical telescopes,it can meet the necessity of the contact ratio and improve the static transmission error,and avoid stress ...
冯锦平, 马文礼
doaj
Contact stresses in gear teeth due to tip relief profile modification [PDF]
, 2011 In this paper the linear tip relief profile modification has been observed. This kind of modification has been considered to be potentially dangerous considering micro-pitting initiation as a consequence of contact pressure increase.
Franulović, Marina, Marković, Kristina
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