Results 111 to 120 of about 1,311,331 (302)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
UNDERCUT AND TOOTH PROFILE MODIFICATION OF DOUBLE HELICAL PULLEY
Jixie qiangdu, 2017 As for the smooth problems in the conjugate surface arising from hob tooth root and flank arc edge during the processing of new double helical synchronous belt’s pulley,the broken line generation mechanism at the conjugate tooth profile was investigated ...
GUO JianHua +3 more
doaj
Profile Modification of Helical Gear Teeth
Bulletin of JSME, 1966 Few investigations are available concerning the profile modification of helical gear teeth and there are many important problems which should be clarified. The object of the present investigation is to find out the effect of the profile modification on the dynamic properties of helical gears, and furthermore to derive the method for determining the ...
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Jixie chuandong, 2010 The tooth profile modification can generally choose straight line modification and parabolic modification.Different modification curves have different modification parameters.In order to accurately determine the best modification curves and modification ...
袁哲, 孙志礼, 郭瑜
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Study on the Precise Modeling Method of Helical Gear with Deviation and Modification
Jixie chuandong, 2018 According to the forming process principle,the influence of the tooth profile modification,helix modification and tooth profile deviation,helix deviation and eccentricity tolerance of radial run-out of the involute helical gear on tooth profile shape is ...
Yuan Yongchao +4 more
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Application of modified profile analysis to function testing of the motion/no-motion issue in an aircraft ground-handling simulation [PDF]
A recent modification of the methodology of profile analysis, which allows the testing for differences between two functions as a whole with a single test, rather than point by point with multiple tests is discussed.
Mckissick, B. T. +2 more
core +1 more source