Results 81 to 90 of about 1,311,331 (302)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Theoretical Research of the Modification of Cycloidal Gear Used in High Precision RV Reducer

Jixie chuandong, 2018
The second-order logarithmic superposition of modification quantity along the normal direction to the theory of conjugate tooth profile of cycloid gear of RV reducer is carried out,the cycloid tooth profile equation after the modification is deduced.
Ke Qingxun, Deng Xiaozhong, Su Jianxin, Nie Shaowu, Geng Longlong, Liang Shuaifeng   +5 more
doaj  

Apollo experience report: Guidance and control systems: CSM service propulsion system gimbal actuators [PDF]

The service propulsion system gimbal actuators of the Apollo command and service module were developed, modified, and qualified between February 1962 and April 1968.
Mcmahon, W. A.
core   +1 more source

Are rotation curves in NGC 6946 and the Milky Way magnetically supported?

, 2005
Following the model of magnetically supported rotation of spiral galaxies, the inner disk rotation is dominated by gravity but magnetism is not negligible at radii where the rotation curve becomes flat, and indeed becomes dominant at very large radii ...
Abadi, Avillez, Barteldrees, Battaner, Battaner, Battaner, Battaner, Battaner, Battaner, Beck, Beck, Beck, Beck, Beck, Berkhuijsen, Beuermann, Brandenburg, Breitschwerdt, Brown, Cuddeford, de Grijs, Diplas, Dziourkevitch, Ferrière, Florido, Fujimoto, Fukugita, Gómez, Han, Hayashi, Heiles, Jokipii, Korpi, Kronberg, Kutschera, Lazarian, Mitra, Navarro, Navarro, Navarro, Nelson, Nishikori, Peratt, Pohlen, Pohlen, Romanovsky, Sánchez-Salcedo, van der Kruit, van der Kruit, van der Kruit, van der Kruit, Walsh, White, Wielebinski, Wielebinski   +54 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Spatial Tooth Profile Design and Optimization Analysis of Involute Harmonic Gear

Jixie chuandong, 2021
In order to improve the meshing performance of the involute tooth profile harmonic gear， the conjugate tooth profile discrete points in design section are obtained with an exact conjugate algorithm using assembly deformation of the flexspline，and the ...
Hongyan Wu, Xiaoxia Chen, Jingzhong Xing
doaj  

Contraction of Dark Matter Halos in Response to Condensation of Baryons

, 2005
The cooling of baryons in the centers of dark matter halos leads to a more concentrated dark matter distribution. This effect has traditionally been calculated using the model of adiabatic contraction, which assumes spherical symmetry, while in ...
Gnedin, Oleg Y.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research on thermal characteristics of gear based on parametric tooth profile modification

Advances in Mechanical Engineering
This paper establishes a thermal analysis model for parametric profile modification gears based on the heat transfer mechanisms of gear transmission. The main research parameters are the addendum coefficient and the modification coefficient, focusing on ...
Hengzhe Shi, Wei Li, Wanlin Zhou
doaj   +1 more source