Results 91 to 100 of about 606,894 (280)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

On Nonparametric Profile Monitoring

open access: yes, 2014
Quality of a process is often characterized by the functional relationship between a response and one or more predictors. Profile monitoring is for checking the stability of this relationship over time. In the literature, most existing control charts are
Qiu, Peihua
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

FEATURES OF BLOOD PRESSURE DAILY PROFILE IN PATIENTS WITH ARTERIAL HYPERTENSION AND IDDM AS ASSESSED BY DAILY BLOOD PRESSURE MONITORING

open access: yesРоссийский кардиологический журнал, 2002
We have conducted the research on revealing conformities of daily profile patients with arterial hypertension with non-insulin-dependent diabetes mellitus as compared with the patients of essential hypertension according to returns of daily blood ...
G. B. Selivanova, A. P. Borisenko
doaj  

Results of hemodynamic profile monitoring in pregnant women with preeclampsia

open access: yesМедицинский вестник Юга России
Оbjective: evaluation of the effectiveness of bioimpedance cardiography for the differential diagnosis of hemodynamic profiles in early and late preeclampsia (PE).Materials and methods: the prospective study included 52 pregnant women: 32 with PE (19 ...
P. J. Zavarzin   +3 more
doaj   +1 more source

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