Results 71 to 80 of about 606,894 (280)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The Progress Mechanism of Track Geometrical Irregularity Focusing on Hanging Sleepers [PDF]

International Journal of Railway Research, 2015
This topic is very traditional and basically has been concerned for a long time. A lot of sophisticated vehicle/track interaction model and track dynamic deterioration model have been developed so far.
Makoto Ishida
doaj  

HEMODYNAMIC AND METABOLIC EFFECTS OF NEBIVOLOL IN LOCOMOTIVE CREW STAFF WITH NEWLY DIAGNOSED ARTERIAL HYPERTENSION

Рациональная фармакотерапия в кардиологии, 2016
Aim. To evaluate influence of long-term monotherapy with nebivolol on blood pressure (BP) (office BP; self-monitoring BP, pre-trip BP monitoring, ambulatory BP monitoring (ABPM)) and metabolic blood profile in locomotive crew staff with newly diagnosed ...
I. V. Osipova, O. N. Antropova, E. I. Bravkova, A. G. Zaltsman, T. B. Belousova, T. V. Perevozchikova, I. A. Batanina   +6 more
doaj   +1 more source

Monitoring of strain profile variations in the RC slab of a short span railway bridge

A novel monitoring scheme oriented towards the structural examination of reinforced concrete slabs subject to railway traffic action is presented. Monitoring is based on the measurement of the mean axial strain profile variation in the cross-section of ...
Brühwiler, Eugen, Grigoriou, Vasileios
core   +1 more source

A General Bayesian Framework for Ellipse-based and Hyperbola-based Damage Localisation in Anisotropic Composite Plates [PDF]

, 2015
This paper focuses on Bayesian Lamb wave-based damage localization in structural health monitoring of anisotropic composite materials. A Bayesian framework is applied to take account for uncertainties from experimental time-of-flight measurements and ...
GUSKOV, Mikhail, MECHBAL, Nazih, RÉBILLAT, Marc, FENDZI, Claude   +3 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Monitoring AerosolPollutant Layer by Lidar Combined with some other Instruments [PDF]

Journal of Systemics, Cybernetics and Informatics, 2006
Lidar is a powerful tool for monitoring vertical profile of aerosol pollutant layer (APL) and its variation. The extinction-to-backscatter ratio, S1, is a crucial parameter for quantitative interpretation of lidar data.
Huanling Hu, Qingshan Xu, Chen Li, Xuebin Li   +3 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating Effect of Autocorrelation on Monitoring Multivariate Linear Profiles

International Journal of Industrial Engineering and Production Research, 2012
Profile monitoring in statistical quality control has attracted attention of many researchers recently. A profile is a function between response variables and one or more independent variables.
Rassoul Noorossana, Paria soleimani
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source