Results 101 to 110 of about 10,838,787 (366)
HIV reprograms progenitor cells [PDF]
Science, 2017 HIV Survival rates of patients with HIV have improved enormously as a result of antiretroviral therapy, but increased life expectancy is now associated with a high risk of comorbidities. HIV–1-associated chronic obstructive pulmonary disease (COPD) often manifests as emphysema, originating around the airways and extending into lung tissue. Chung et al.
openaire +3 more sources
FEBS Open Bio, EarlyView.Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura +7 more
wiley +1 more source
Translation From Mice to Men: Are Dogs a Dodgy Intermediate? [PDF]
European Medical Journal Hepatology, 2014 Alternatives for liver transplantation in severe liver disease are urgently needed in view of the limited availability of donor livers. The use of embryonic stem cells (ES) or hepatic progenitor cells (HPC) has been investigated in mice models of acute ...
Hedwig S. Kruitwagen +5 more
doaj
FEBS Open Bio, EarlyView.This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li +10 more
wiley +1 more source
ANGIOGENIC BLOOD CELLS AFTER LIVER TRANSPLANTATION
Вестник трансплантологии и искусственных органов, 2012 Blood cells involved in neovascularisation were studied with flow-cytometry in the cadaver liver transplant recipients. The signs of «turbulent» state of bone marrow reproductive activity were found and assessed as features of its progressive exhaustion.
A. N. Shutko +3 more
doaj +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
Stem Cell Reports, 2016 Much of our understanding about how intestinal stem and progenitor cells are regulated comes from studying the late fetal stages of development and the adult intestine.
Alana M. Chin +8 more
doaj +1 more source
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
Nature Cell Biology, 2013 Present models suggest that the fate of the kidney epithelial progenitors is solely regulated by signals from the adjacent ureteric bud. The bud provides signals that regulate the survival, renewal and differentiation of these cells.
Amrita Das +8 more
semanticscholar +1 more source
Central Dysmyelination in SSADH‐Deficient Humans and Mice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer +11 more
wiley +1 more source
Disease Models & Mechanisms, 2018 The final nephron number in an adult kidney is regulated by nephron progenitor cell availability and collecting duct branching in the fetal period. Fetal environmental perturbations that cause reductions in cell numbers in these two compartments result ...
Sree Deepthi Muthukrishnan +3 more
doaj +1 more source