Results 101 to 110 of about 11,013,611 (366)

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

Neural Regeneration Research
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination. Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.
Jian Yang, Jiang Wu, Xueshun Xie, Pengfei Xia, Jinxin Lu, Jiale Liu, Lei Bai, Xiang Li, Zhengquan Yu, Haiying Li   +9 more
doaj   +1 more source

Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney

Disease Models & Mechanisms, 2018
The final nephron number in an adult kidney is regulated by nephron progenitor cell availability and collecting duct branching in the fetal period. Fetal environmental perturbations that cause reductions in cell numbers in these two compartments result ...
Sree Deepthi Muthukrishnan, Sergey Ryzhov, Michele Karolak, Leif Oxburgh   +3 more
doaj   +1 more source

Niche stiffness underlies the aging of central nervous system progenitor cells

Nature, 2019
Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell and progenitor cell populations1. One example is the deterioration of the regenerative capacity of the widespread and abundant population of central nervous ...
Michael Segel, Björn Neumann, M. Hill, Isabell P. Weber, C. Viscomi, Chao Zhao, Adam M. H. Young, Chibeza C. Agley, Amelia J Thompson, G. Gonzalez, Amar Sharma, S. Holmqvist, D. Rowitch, K. Franze, R. Franklin, K. Chalut   +15 more
semanticscholar   +1 more source

Transparent Inorganic–Organic Bilayer Neural Electrode Array and Integration to Miniscope System for In Vivo Calcium Imaging and Electrophysiology

Advanced Functional Materials, EarlyView.
This study presents the BioCLEAR system, a highly transparent and conductive neural electrode array composed of silver nanowires (AgNWs) and doped PEDOT:PSS, enabling neural recordings with minimal optical artifacts. When integrated with a GRIN lens, this cost‐effective neural implant allows simultaneous electrophysiological recording and GCaMP6‐based ...
Dongjun Han, Kevin Cheng, Swathy Sampath Kumar, Anil Bollimunta, Elizabeth E. Torr, Juhwan Kim, Kyoungmin Kim, Hyungjun Choi, Seongkwon Hwang, Sarah Brodnick, David Cheng, Lindsay Gray, Yei Hwan Jung, William L. Murphy, Aaron J. Suminski, Jonathan J. Nassi, Justin C. Williams, Dong‐Wook Park   +17 more
wiley   +1 more source

One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo

Neural Regeneration Research
Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.
Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wang   +12 more
doaj   +1 more source

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, EarlyView.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Translation From Mice to Men: Are Dogs a Dodgy Intermediate? [PDF]

European Medical Journal Hepatology, 2014
Alternatives for liver transplantation in severe liver disease are urgently needed in view of the limited availability of donor livers. The use of embryonic stem cells (ES) or hepatic progenitor cells (HPC) has been investigated in mice models of acute ...
Hedwig S. Kruitwagen, Bart Spee, Hille Fieten, Frank G. van Steenbeek, Baukje A. Schotanus, Louis C. Penning   +5 more
doaj  

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways [PDF]

, 2018
Ying Yang, Paul Riccio, Michael Schotsaert, Munemasa Mori, Jining Lü, Dong-Kee Lee, Adolfo Garcı́a-Sastre, Jianming Xu, Wellington V. Cardoso   +8 more
openalex   +1 more source

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation

Biology Open, 2013
Summary Epithelial organ morphogenesis involves reciprocal interactions between epithelial and mesenchymal cell types to balance progenitor cell retention and expansion with cell differentiation for evolution of tissue architecture.
Deirdre A. Nelson, Charles Manhardt, Vidya Kamath, Yunxia Sui, Alberto Santamaria-Pang, Ali Can, Musodiq Bello, Alex Corwin, Sean R. Dinn, Michael Lazare, Elise M. Gervais, Sharon J. Sequeira, Sarah B. Peters, Fiona Ginty, Michael J. Gerdes, Melinda Larsen   +15 more
doaj   +1 more source