Advanced Science, EarlyView.This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu +10 more
wiley +1 more source
LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity. [PDF]
Commun Med (Lond)Loh NY +14 more
europepmc +1 more source
Peripheral blood blast cell progenitors in human preleukemia [PDF]
, 1982 JS Senn +5 more
openalex +1 more source
Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease
Advanced Science, EarlyView.Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and extracellular matrix stiffening. An in vitro NAFLD model is developed using engineered hydrogels (G′ ≈ 1–6 kPa) and iPSC‐derived hepatic organoids. It is demonstrated that higher stiffness can increase lipid droplet accumulation, fibrosis, and metabolic dysregulation ...
Yueming Liu +11 more
wiley +1 more source
Protocol for the isolation and characterization of murine hematopoietic stem and progenitor cell-derived extracellular vesicles. [PDF]
STAR ProtocZanotti F +7 more
europepmc +1 more source
Limiting-dilution analysis of the effects of colony-stimulating factors, phytohemagglutinin, and hydrocortisone on hematopoietic progenitor cell growth [PDF]
, 1987 Yoichi Takaue +6 more
openalex +1 more source
Advanced Science, EarlyView.Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye +13 more
wiley +1 more source
Unlocking lung regeneration: insights into progenitor cell dynamics and metabolic control. [PDF]
Cell RegenYang J, Li Y, Huang Y, Chen H, Sui P.
europepmc +1 more source
T cells in B cell chronic lymphocytic leukemia. II. Lack of antigen-specific T suppressor cells and their progenitors. [PDF]
, 1985 A C Bloem +3 more
openalex +1 more source
Advanced Science, EarlyView.A novel interpenetrating network hydrogel microsphere (NSC‐Exos@HIMS) is developed to manipulate oxygen tension in damaged regions and recruit endogenous stem cells. In vitro and in vivo results show that NSC‐Exos@HIMS maintains the hypoxia microenvironment for up to 5 days, which triggers nucleus pulposus cell‐like differentiation and enhanced ECM ...
Xingdie Zhou +9 more
wiley +1 more source