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Expansion of stem and progenitor cells
Current Opinion in Hematology, 1998An increasing interest exists in strategies to manipulate hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) in vitro for clinical purposes by use of recombinant hematopoietic growth factors. A major goal of these ex vivo expansion strategies is to expand repopulating HSCs or to generate lineage-committed progenitors in the ...
Lothar Kanz, Benedikt L. Ziegler
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Relaxin' with endothelial progenitor cells
Blood, 2012Segal and colleagues in this issue of Blood report their findings about an additional new function for the hormone relaxin: turning on bone marrow–derived endothelial progenitor cells to sites of neoangiogenesis ...
Alice Wang, S. Ananth Karumanchi
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Progenitor cells in the adult pancreas
Diabetes/Metabolism Research and Reviews, 2004AbstractThe β‐cell mass in the adult pancreas possesses the ability to undergo limited regeneration following injury. Identifying the progenitor cells involved in this process and understanding the mechanisms leading to their maturation will open new avenues for the treatment of type 1 diabetes.
L. Jorge Góñez +2 more
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Progenitor cells and retinal angiogenesis
Angiogenesis, 2007Nothing more dramatically captures the imagination of the visually impaired patient or the ophthalmologist treating them than the possibility of rebuilding a damaged retina or vasculature with "stem cells." Stem cells (SC) have been isolated from adult tissues and represent a pool of cells that may serve to facilitate rescue/repair of damaged tissue ...
Mohammad A. El-Kalay +8 more
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Cytokinetics and regulation of progenitor cells
Journal of Cellular Physiology, 1966Four different assay methods of bone marrow stem cells have been examined with regard to the kinetic pattern following perturbation of the steady-state system, e.g., by irradiation. Basically, the stem cell assays fall into two categories: those depending on grafting hemopoietic cells into suitably treated recipients, and those in which recovery of the
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Glia as neural progenitor cells
Trends in Neurosciences, 2003Recent studies have substantially expanded our conception of the roles for glia in function and maintenance of the adult nervous system. Of these reports, several have re-examined the lineage relationships among neural stem cells, their early radial glial derivatives and their mitotically competent neurogenic daughters.
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Progenitor cells in vascular repair
Current Opinion in Lipidology, 2007A common characteristic of all types of vascular disease is endothelial dysfunction/damage followed by an inflammatory response. Although mature endothelial cells can proliferate and replace damaged cells in the vessel wall, recent findings indicate an impact of stem and progenitor cells in repair process.
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AMPK and Placental Progenitor Cells
2016AMPK is important in numerous physiological systems but plays a vital role in embryonic and placental development. The placenta is a unique organ that is the essential lifeline between the mother and baby during pregnancy and gestation. During placental development, oxygen concentrations are very low until cells differentiate to establish the ...
Melissa R. Kaufman, Tom Brown
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Progenitor Cells in the Pulmonary Circulation
Proceedings of the American Thoracic Society, 2011The mechanisms involved in the regulation of pulmonary vascular endothelial cells to replace aged or injured cells remains poorly understood, although differences in proliferative potential between the microvascular and macrovascular endothelium are well described.
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Hematopoietic Progenitor Cell Collection
2012Hematopoietic progenitor cells can be mobilized from the bone marrow microenvironment into the peripheral blood following treatment of patients with myeloid cytokines (GCSF, GMCSF, IL3), a CXCR4 antagonist (Plerixafor) and/or following a hematopoietic recovery from cytotoxic chemotherapy. The hematopoietic stem and progenitor cells are contained within
S. Darlene Marlow, Myra House
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