Results 291 to 300 of about 569,127 (341)
Distinct chemical structures inhibit the CEMIP hyaluronidase and promote oligodendrocyte progenitor cell maturation. [PDF]
Peters A+11 more
europepmc +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen+6 more
wiley +1 more source
Cordycepin Activates Autophagy to Suppress FGF9-induced TM3 Mouse Leydig Progenitor Cell Proliferation. [PDF]
Wu SZ+4 more
europepmc +1 more source
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia+9 more
wiley +1 more source
Large‐scale generation of disc‐shaped models mimicking human epiblast layer is achieved by bioprinting of human pluripotent stem cells using a well‐defined biomatrix. The bioactive component and physical confinement from laminin/alginate microgels, combined with the endogenous regulation of the WNT signaling pathway regulated disc‐like morphogenesis ...
Yixue Luo+11 more
wiley +1 more source
Possible cause of clot in hematopoietic progenitor cell product: Procoagulant activity or inadequate anticoagulation? [PDF]
Gupta S+4 more
europepmc +1 more source
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo+11 more
wiley +1 more source
Hepatic progenitor cell activation and ductular reaction in metabolic dysfunction-associated steatotic liver disease (MASLD): Indicators for disease activity and the degree of fibrosis: The pilot study. [PDF]
Büyük M+4 more
europepmc +1 more source
Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks
The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie+7 more
wiley +1 more source