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Progenitor cells in the adult pancreas
Diabetes/Metabolism Research and Reviews, 2004AbstractThe β‐cell mass in the adult pancreas possesses the ability to undergo limited regeneration following injury. Identifying the progenitor cells involved in this process and understanding the mechanisms leading to their maturation will open new avenues for the treatment of type 1 diabetes.
Andrew M, Holland +2 more
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Endothelial progenitor cells and thrombosis
Thrombosis Research, 2012The remodelling of existing vessels (i.e. angiogenesis) and the "de novo" vessel formation (i.e. vasculogenesis) occur not only during the embryonic development but also over the entire postnatal life. In 1997, the Asahara group first reported that endothelial progenitor cells circulate in peripheral blood and that they are recruited at sites of ...
Eugenia Rosa, Nuzzolo +2 more
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Expansion of stem and progenitor cells
Current Opinion in Hematology, 1998An increasing interest exists in strategies to manipulate hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) in vitro for clinical purposes by use of recombinant hematopoietic growth factors. A major goal of these ex vivo expansion strategies is to expand repopulating HSCs or to generate lineage-committed progenitors in the ...
B L, Ziegler, L, Kanz
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Relaxin' with endothelial progenitor cells
Blood, 2012Segal and colleagues in this issue of Blood report their findings about an additional new function for the hormone relaxin: turning on bone marrow–derived endothelial progenitor cells to sites of neoangiogenesis ...
Alice, Wang, S Ananth, Karumanchi
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Progenitor cells and retinal angiogenesis
Angiogenesis, 2007Nothing more dramatically captures the imagination of the visually impaired patient or the ophthalmologist treating them than the possibility of rebuilding a damaged retina or vasculature with "stem cells." Stem cells (SC) have been isolated from adult tissues and represent a pool of cells that may serve to facilitate rescue/repair of damaged tissue ...
Martin, Friedlander +8 more
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Endothelial progenitor cells and preeclampsia
Frontiers in Bioscience, 2007The maternal cardiovascular adaptation to pregnancy involves a complex physiologic response to the presence of the growing conceptus, including alterations in maternal vascular endothelial cells that contribute to a profound fall in total systemic vascular resistance.
Hilary S, Gammill +2 more
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Neural progenitors and stem cells: mechanisms of progenitor heterogeneity
Current Opinion in Neurobiology, 1998Heterogeneity among progenitor cells in the vertebrate nervous system has been documented with increasing frequency over the past few years. It has become clear that differences in progenitor cells help to determine when and how they respond to environmental signals.
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Stromal Mesenchymal Progenitor Cells
Leukemia & Lymphoma, 1999The precursors of bone, cartilage, fat and muscle cells are likely to be derived from more primitive mesenchymal cells which exhibit some of the characteristics of stem cells. Despite extensive study of stromal cell differentiation, neither mesenchymal stem cells or the more committed, tissue-specific progenitors have been well characterized.
R, Ghilzon, C A, McCulloch, R, Zohar
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B cells talk to their progenitors
Blood, 2011In this issue of Blood, Keren and colleagues report the existence of novel aging-associated cross-talk between the peripheral B-cell compartment and progenitors in the bone marrow, which negatively regulates B-cell production.1 This pathway could represent a target for therapeutic intervention in aged individuals who suffer from recurrent infection ...
Arnaud, Van Den Broeck, John, Cambier
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Cytokinetics and regulation of progenitor cells
Journal of Cellular Physiology, 1966Four different assay methods of bone marrow stem cells have been examined with regard to the kinetic pattern following perturbation of the steady-state system, e.g., by irradiation. Basically, the stem cell assays fall into two categories: those depending on grafting hemopoietic cells into suitably treated recipients, and those in which recovery of the
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