Results 81 to 90 of about 10,838,787 (366)
Neural Regeneration ResearchDifferentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination. Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.
Jian Yang +9 more
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Improving the viability of tissue‐resident stem cells using an organ‐preservation solution
FEBS Open Bio, 2019 Human clinical specimens are a valuable source of tissue‐resident stem cells, but such cells need to be collected immediately after tissue collection. To extend the timescale for collection from fresh human samples, we developed a new extracellular fluid
Takaya Suzuki +8 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, inflammation, and oxidative stress. This study investigated the association of plasma PCSK9 levels with the presence and severity of peripheral artery
Ting‐Hsing Chao +4 more
doaj +1 more source
Progenitor cells in vascular disease [PDF]
Journal of Cellular and Molecular Medicine, 2005 Stem cell research has the potential to provide solutions to many chronic diseases via the field of regeneration therapy. In vascular biology, endothelial progenitor cells (EPCs) have been identified as contributing to angiogenesis and hence have therapeutic potential to revascularise ischaemic tissues.
Neil Roberts +2 more
openaire +3 more sources
SensRORing cholesterol to drive protumoral myelopoiesis
Molecular Oncology, EarlyView.Bleve et al. uncover a cholesterol‐driven immune evasion pathway, where RORγ‐dependent myelopoiesis shapes tumor immunosuppression. Targeting RORγ and PCSK9 emerges as a strategy to boost cancer immunotherapy. Protumoral myelopoiesis is a determinant of immunoevasion and tumor spread in many malignancies.
Sara Gennari, Luigi Nezi, Teresa Manzo
wiley +1 more source
The Musashi family RNA-binding proteins in stem cells
Biomolecular Concepts, 2010 The Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date.
Horisawa Kenichi +3 more
doaj +1 more source
Modeling neural differentiation on micropatterned substrates coated with neural matrix components
Frontiers in Cellular Neuroscience, 2012 Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo.
Patricia eGarcía-Parra +9 more
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A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
Journal of Neuroscience, 1992 The mitogenic actions of epidermal growth factor (EGF) were examined in low-density, dissociated cultures of embryonic day 14 mouse striatal primordia, under serum-free defined conditions.
B. Reynolds, W. Tetzlaff, S. Weiss
semanticscholar +1 more source
Derivation of Myoepithelial Progenitor Cells from Bipotent Mammary Stem/Progenitor Cells
PLoS ONE, 2012 There is increasing evidence that breast and other cancers originate from and are maintained by a small fraction of stem/progenitor cells with self-renewal properties. Recent molecular profiling has identified six major subtypes of breast cancer: basal-like, ErbB2-overexpressing, normal breast epithelial-like, luminal A and B, and claudin-low subtypes.
Hamid Band +3 more
openaire +5 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source