Results 81 to 90 of about 569,127 (341)

Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney

Disease Models & Mechanisms, 2018
The final nephron number in an adult kidney is regulated by nephron progenitor cell availability and collecting duct branching in the fetal period. Fetal environmental perturbations that cause reductions in cell numbers in these two compartments result ...
Sree Deepthi Muthukrishnan, Sergey Ryzhov, Michele Karolak, Leif Oxburgh   +3 more
doaj   +1 more source

Human Cytomegalovirus Infection Suppresses CD34⁺ Progenitor Cell Engraftment in Humanized Mice

Microorganisms, 2020
Human cytomegalovirus (HCMV) infection is a serious complication in hematopoietic stem cell transplant (HSCT) recipients due to virus-induced myelosuppression and impairment of stem cell engraftment.
Lindsey B. Crawford, Rebecca Tempel, Daniel N. Streblow, Andrew D. Yurochko, Felicia D. Goodrum, Jay A. Nelson, Patrizia Caposio   +6 more
doaj   +1 more source

Progenitor cells in vascular disease [PDF]

Journal of Cellular and Molecular Medicine, 2005
Stem cell research has the potential to provide solutions to many chronic diseases via the field of regeneration therapy. In vascular biology, endothelial progenitor cells (EPCs) have been identified as contributing to angiogenesis and hence have therapeutic potential to revascularise ischaemic tissues.
Neil Roberts, Qingbo Xu, Marjan Jahangiri   +2 more
openaire   +3 more sources

Transcriptional profiling of SNAI2 regulated genes in primary human keratinocytes. [PDF]

, 2015
Epithelial to mesenchymal transition transcription factors (EMT-TFs) such as SNAI2 have been found to be expressed endogenously in epidermal stem and progenitor cells and downregulated upon differentiation.
Chen, Yifang, Mistry, Devendra S, Sen, George L, Wang, Ying   +3 more
core   +3 more sources

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Some International Constitutional Aspects of the Palestine Case [PDF]

, 1968
Cardiac tissue engineering via the use of stem cells is the future for repairing impaired heart function that results from a myocardial infarction.
Gelmi, Amy, Jager, Edwin, Kozak Ljunggren, Monika, Rafat, Mehrdad   +3 more
core   +2 more sources

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Elevated in Patients With Peripheral Artery Disease and Associated With Metabolic Disorders and Dysfunction in Circulating Progenitor Cells

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in cholesterol homeostasis, inflammation, and oxidative stress. This study investigated the association of plasma PCSK9 levels with the presence and severity of peripheral artery
Ting‐Hsing Chao, I‐Chih Chen, Yi‐Heng Li, Po‐Tseng Lee, Shih‐Ya Tseng   +4 more
doaj   +1 more source

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. [PDF]

, 2019
Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific gene networks results in birth defects, which affect 5% of live births.
de Soysa, T Yvanka, Del Sol, Antonio, Gifford, Casey A, Huang, Yu, Okawa, Satoshi, Ranade, Sanjeev S, Ravichandran, Srikanth, Salunga, Hazel T, Schricker, Amelia, Srivastava, Deepak   +9 more
core  

Proliferation versus Differentiation: Redefining Retinoic Acids Role. [PDF]

, 2018
Retinoic acid is commonly used in culture to differentiate stem cells into neurons and has established neural differentiation functions in vivo in developing and adult organisms. In this issue of Stem Cell Reports, Mishra et al.
Mosher, Kira, SCHAFFER, David
core   +1 more source