Results 171 to 180 of about 234,306 (316)

Integrated Analysis of Genetic, Spectral, Phenotypic, and Stress-Resistant Traits in <i>Vanda</i> × <i>Papilionanthe</i> Intergeneric Hybrids. [PDF]

Plants (Basel)
Li H, Cui XQ, Zhang ZB, Li JW.
europepmc   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Chromosome-specific differences in the recombination landscape of spontaneous meiotic nondisjunction. [PDF]

Genetics
Turcotte CA, Sekelsky J.
europepmc   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Dietary restriction shapes intergenerational ribosome abundance and early growth of Caenorhabditis elegans offspring. [PDF]

PLoS Biol
Pradhan S, Stojanovski K, Dellemann F, Psalmon S, Tuomaala J, Stroustrup NE, Towbin BD.   +6 more
europepmc   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Prolificacy-survival trade-off in Morada Nova sheep under Brazilian semiarid conditions. [PDF]

Trop Anim Health Prod
Silveira RMF, Pereira AHR, Balistrieri M, Cortat PR, de Moraes Silva K, Carrara ER, Mcmanus C, Landim AV.   +7 more
europepmc   +1 more source

ApoE‐ and Cfh‐deficient mice exhibit structural and molecular features of human early–intermediate retinal degeneration

Animal Models and Experimental Medicine, EarlyView.
Age‐related macular degeneration (AMD) involves lipid dysregulation and complement overactivation. Here, we characterize a double‐knockout ApoE−/−/Cfh−/− mouse as a model of early–intermediate retinal degeneration. These mice exhibit retinal pigment epithelium thinning, Bruch's membrane thickening, lipid accumulation, enhanced C5b‐9 deposition ...
Sergio Recalde, Maite Moreno Orduña, Jaione Bezunartea, Idoia Belza, Ainara Chas, Laura Fernández‐Sánchez, Nicolás Cuenca Navarro, Alfredo García‐Layana, Patricia Fernández‐Robredo, María Hernández   +9 more
wiley   +1 more source

Engineering plant architecture in the ornamental species Eustoma grandiflorum by knockout of strigolactone biosynthesis. [PDF]

Plant Cell Rep
Yamaguchi K, Tomizawa E, Kanematsu N, Sakaguchi K, Kasai T, Ebisawa R, Hasumi A, Kawakatsu K, Osakabe Y, Osakabe K, Nakatsuka T.   +10 more
europepmc   +1 more source