Results 271 to 280 of about 17,639 (297)
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Lonafarnib for cancer and progeria
Expert Opinion on Investigational Drugs, 2012Lonafarnib is a non-peptidomimetic inhibitor of farnesyl transferase, an enzyme responsible for the post-translational lipid modification of a wide variety of cellular proteins that are involved in the pathogenic pathways of various diseases including cancer and progeria.
Nan Soon Wong, Michael A. Morse
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Archives of Dermatology, 1973
A new case with the typical features of progeria (Hutchinson-Gilford) occurred. Histology of scleroderma-like skin revealed hyalinization of the connective tissue at the lower levels of the dermis and marked reduction of the subcutaneous tissue. Scanning electron microscopy of scalp hairs revealed abnormal longitudinal depressions with minor cuticular ...
Raul Fleischmajer, Alexander Nedwich
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A new case with the typical features of progeria (Hutchinson-Gilford) occurred. Histology of scleroderma-like skin revealed hyalinization of the connective tissue at the lower levels of the dermis and marked reduction of the subcutaneous tissue. Scanning electron microscopy of scalp hairs revealed abnormal longitudinal depressions with minor cuticular ...
Raul Fleischmajer, Alexander Nedwich
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Reprogramming aging and progeria
Current Opinion in Cell Biology, 2012The aging rate of an organism depends on the ratio of tissue degeneration to tissue repair. As a consequence, molecular alterations that tip this balance toward degeneration cause accelerated aging. Conversely, interventions can be pursued to reduce tissue degeneration or to increase tissue repair with the aim of delaying the onset of age-associated ...
José M.P. Freije, Carlos López-Otín
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Pediatrics, 2007
Progeria (Hutchinson-Gilford progeria syndrome) is a rare genetic disorder that offers considerable insight into the biology of premature aging. This review summarizes the clinical characteristics of this disease and the underlying mutation in the lamin A (LMNA) gene that results in this phenotype.
Leslie B. Gordon +2 more
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Progeria (Hutchinson-Gilford progeria syndrome) is a rare genetic disorder that offers considerable insight into the biology of premature aging. This review summarizes the clinical characteristics of this disease and the underlying mutation in the lamin A (LMNA) gene that results in this phenotype.
Leslie B. Gordon +2 more
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The Nuclear Envelope in Ageing and Progeria.
Sub-cellular biochemistry, 2023Adrián Fragoso-Luna, P. Askjaer
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The Journal of Pediatrics, 1960
S I N c e . Gilford 1 introduced the term "progeria" in 1904 fewer than 30 typical cases have been reported. A thorough review of the literature with full description of the syndrome has been made by Thomson and Forfar in 19502 and by Gabr in 19547 Several cases have been described subsequently.
M. Hashem +4 more
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S I N c e . Gilford 1 introduced the term "progeria" in 1904 fewer than 30 typical cases have been reported. A thorough review of the literature with full description of the syndrome has been made by Thomson and Forfar in 19502 and by Gabr in 19547 Several cases have been described subsequently.
M. Hashem +4 more
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Anaesthesia for a child with progeria
Pediatric Anesthesia, 2001The Hutchinson–Gilford syndrome, commonly referred to as progeria, is a rare childhood syndrome that results in premature ageing. We focus on two anaesthetics administered to a child with progeria and a review of the available literature.
James F. Mayhew, Nhung H. Nguyen
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Radiology, 1962
Progeria is a rare disease of unknown etiology characterized by premature senility, retarded development, and death at an early age. Its roentgenographic features have been mentioned briefly in the study of about 30 cases reported since Hutchinson's original publication in 1886 (3, 5, 7, 10).
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Progeria is a rare disease of unknown etiology characterized by premature senility, retarded development, and death at an early age. Its roentgenographic features have been mentioned briefly in the study of about 30 cases reported since Hutchinson's original publication in 1886 (3, 5, 7, 10).
openaire +3 more sources