Results 21 to 30 of about 13,996 (187)
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone
Signal Transduction and Targeted Therapy, 2022 Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic. We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice.
Shan Su +12 more
doaj +1 more source
International Journal of Reproductive BioMedicine, 2022 Background: Luteal phase deficiency is common in assisted reproductive technology and is characterized by inadequate progesterone production. Various studies have shown that administration of progesterone in fresh embryo transfer cycles increases the ...
Samaneh Jalaliani +4 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2011 Purpose: Bioavailability of transdermal progesterone is low and variable. This may be attributed to transdermal metabolism by the 5α-reductase enzymes or the direct transport to the saliva. The objective of the current study was to evaluate the effect of
sara Zargar-Shoshtari +4 more
doaj +1 more source
Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial
International Journal of Endocrinology, 2015 Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design.
Kathryn S. Merriam +5 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2015 In women, high levels of natural progesterone have been associated with detrimental cognitive effects via the maternal amnesia phenomenon as well as in controlled experiments.
B. Blair Braden +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Steroid hormone bioavailability is controlled by the lymphatic system
Scientific Reports, 2021 The steroid hormone progesterone accounts for immune tolerance in pregnancy. Enhanced progesterone metabolism to 6α-OH-pregnanolone occurs in complicated pregnancies such as in preeclampsia with preterm delivery or intrauterine growth restriction, and in
Rahel Klossner +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females. [PDF]
PLoS Pathogens, 2016 Over 100 million women use progesterone therapies worldwide. Despite having immunomodulatory and repair properties, their effects on the outcome of viral diseases outside of the reproductive tract have not been evaluated.
Olivia J Hall +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source