Results 81 to 90 of about 328,870 (293)

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Progesterone and Follicle Stimulating Hormone interact and promote goat preantral follicles survival and development in vitro

Pesquisa Veterinária Brasileira, 2012
We investigated the effects of progesterone and follicle stimulating hormone (FSH) on survival and growth of caprine preantral follicles. Pieces of ovarian tissue were cultured for 1 or 7 days in minimum essential medium (MEM) alone or containing ...
Isabel B. Lima-Verde, Maria H.T. Matos, Juliana J.H. Celestino, Rafael Rossetto, Khesller P.O. Name, Sônia N. Báo, Cláudio C. Campello, José R. Figueiredo   +7 more
doaj   +1 more source

Progesterone activation of β1-containing BK channels involves two binding sites

Nature Communications, 2023
Progesterone (≥1 µM) is used in recovery of cerebral ischemia, an effect likely contributed to by cerebrovascular dilation. The targets of this progesterone action are unknown.
Kelsey C. North, Andrew A. Shaw, Anna N. Bukiya, Alex M. Dopico   +3 more
doaj   +1 more source

Les variations saisonnières de la reproduction des bovins domestiques en zone tropicale. Synthèse [PDF]

, 2009
En zone tropicale, les climats sont variés. L'environnement agit sur la reproduction par voie nerveuse et par voie hormonale. Les températures élevées, dépassant une température critique qui dépend de la race (stress thermique), sont nuisibles aux ...
Meyer, Christian
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Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Comparison of the efficacy of vaginal micronised progesterone tablet and gel for in vitro fertilisation

Journal of Obstetrics and Gynaecology
Background Luteal phase support (LPS) with progesterone is a generally accepted practice after controlled ovarian stimulation, although the best protocols for LPS have been debated.
Soo Jin Han, Hoon Kim, Yun Soo Hong, Sung Woo Kim, Seung-Yup Ku, Chang Suk Suh   +5 more
doaj   +1 more source

Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats

Scientific Reports, 2017
Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse frequency. Recent studies reported that progesterone prevented premature LH surges during ovarian hyperstimulation in women. As the most potent stimulator of GnRH/LH release,
Wen He, Xiaofeng Li, Daniel Adekunbi, Yali Liu, Hui Long, Li Wang, Qifeng Lyu, Yanping Kuang, Kevin T. O’Byrne   +8 more
doaj   +1 more source

Effects of Levonorgestrel and progesterone on Oviductal physiology in mammals

Reproductive Biology and Endocrinology, 2018
Background Our previous study indicated that emergency contraception, including levonorgestrel and progesterone, could lead to ectopic pregnancy following contraception failure. However, our understanding of the effects of levonorgestrel and progesterone
Cheng Li, Hui-Yu Zhang, Yan Liang, Wei Xia, Qian Zhu, Duo Zhang, Zhen Huang, Gui-Lin Liang, Rui-Hong Xue, Hang Qi, Xiao-Qing He, Jiang-Jing Yuan, Ya-Jing Tan, He-Feng Huang, Jian Zhang   +14 more
doaj   +1 more source

Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia

Cell Transplantation, 2023
We aimed to explore whether the effect of progesterone on preeclampsia via the PI3K/AKT signaling pathway. First, we studied the role of progesterone in preeclampsia patients and HTR-8/Svneo cells by adding progesterone.
Hongyu Liu, Ling Yu, Yiling Ding, Mei Peng, Yali Deng   +4 more
doaj   +1 more source

Les kystes folliculaires chez la vache laitière : évaluation échographique de l'efficacité d'un traitement par les progestagènes et relation avec l'inflammation génitale [PDF]

, 2013
Le kyste folliculaire pathologique est une affection courante chez la vache laitière, entrainant des troubles de la reproduction. L’efficacité d’un traitement à base du progestagène « CRESTAR SO® » a été évaluée grâce à un suivi échographique.
Dornier, Pauline, Droui, Xavier
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