Results 121 to 130 of about 362,542 (345)
Clinical Pharmacology in Drug Development, EarlyView.Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi +8 more
wiley +1 more source
Supplementing Single‐Arm Trials with External Control Arms—Evaluation of German Real‐World Data
Clinical Pharmacology &Therapeutics, EarlyView.As single‐arm trials (SATs) are increasingly used in pharmaceutical research, the validity of such study designs needs to be critically assessed. We characterize the feasibility of supplementing SATs with real‐world data (RWD)‐derived external control arms by determining the proportion of SATs on breast cancer and amyotrophic lateral sclerosis (ALS ...
Martin Russek +2 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Introduction Ovarian hormones (i.e., estradiol, progesterone) show robust phenotypic associations with binge eating and related behaviors (e.g., emotional eating) in females. Recent research suggests these associations may be due to ovarian hormone effects on genetic and environmental influences on dysregulated eating. However, no research has
Megan E. Mikhail +8 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source
Progesterone in the Blood of the Laying Hen [PDF]
, 1958 Ivan M. Lytle, F.W. Lorenz
openalex +1 more source
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval +2 more
wiley +1 more source
Some Effects of Acth, Cortisone, Progesterone and Testosterone on Sebaceous Glands in the White Rat1
, 1953 D. M. Haskin +2 more
openalex +1 more source
Toward a working definition of ketogenic diet resistance in GLUT1 deficiency syndrome
Epileptic Disorders, EarlyView.Abstract Objective The ketogenic diet (KD) is the standard treatment for glucose transporter type 1 deficiency syndrome (GLUT1‐DS), typically yielding seizure reduction and cognitive/motor gains. However, a small subset of patients shows limited or no clinical benefit.
Raffaele Falsaperla +8 more
wiley +1 more source