Results 311 to 320 of about 403,170 (356)
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Journal of Steroid Biochemistry, 1979
Abstract The effect of progesterone (P) treatment on P receptors and on the resultant P concentrations in the cytoplasm and other subcellular fractions was studied. Cytoplasmic P receptors in the uterus of oestrogenized rabbits were reduced by about 60% after 24 h of single injection of P.
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Abstract The effect of progesterone (P) treatment on P receptors and on the resultant P concentrations in the cytoplasm and other subcellular fractions was studied. Cytoplasmic P receptors in the uterus of oestrogenized rabbits were reduced by about 60% after 24 h of single injection of P.
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A radioimmunoassay for progesterone
Steroids, 1972Abstract The need for a simple and fast quantitative method for progesterone with routine laboratory and clinical application motivated the development of a radioimmunoassay. Progesterone antibodies were produced in rabbits by immunization with a bovine serum albumin conjugate of 11α-hydroxyprogesterone hemisuccinate.
J M, Spieler +3 more
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European Journal of Obstetrics & Gynecology and Reproductive Biology, 2001
The role of progesterone (P) in the mechanism of ovulation is controversial at best. The contraceptive application of P was established in rodents in 1936 and with orally absorbed progestogenes was put to human use. There were hints on the proovulatory actions of P administered before the time of ovulation in rats by 1948.
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The role of progesterone (P) in the mechanism of ovulation is controversial at best. The contraceptive application of P was established in rodents in 1936 and with orally absorbed progestogenes was put to human use. There were hints on the proovulatory actions of P administered before the time of ovulation in rats by 1948.
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Current Opinion in Obstetrics & Gynecology, 2005
Progesterone is an essential hormone in the process of reproduction. Although the pharmacokinetics and pharmacodynamics of progesterone have been well studied, its use in the pathophysiology of pregnancy remains controversial. One of these concerns is the way in which the hormone is administered.In obstetrics the most frequent uses of progesterone are ...
Gian Carlo, Di Renzo +3 more
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Progesterone is an essential hormone in the process of reproduction. Although the pharmacokinetics and pharmacodynamics of progesterone have been well studied, its use in the pathophysiology of pregnancy remains controversial. One of these concerns is the way in which the hormone is administered.In obstetrics the most frequent uses of progesterone are ...
Gian Carlo, Di Renzo +3 more
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Annals of the New York Academy of Sciences, 2005
Abstract: Recent clinical trials in hormone therapy (HT) for women approaching or past menopause have been disappointing. Most women who have been taking conjugated equine estrogens combined with synthetic progestins have been encouraged to stop these supplements because of increased health risks.
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Abstract: Recent clinical trials in hormone therapy (HT) for women approaching or past menopause have been disappointing. Most women who have been taking conjugated equine estrogens combined with synthetic progestins have been encouraged to stop these supplements because of increased health risks.
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Spinimmunoassay of progesterone
Biochemical and Biophysical Research Communications, 1975Abstract A spin-labeled derivative of progesterone was prepared: 3(progesterone-1111α-hemisuccinyl)-3 methylamino-2,2,5,5, tetramethyl pyrolidine-1-oxyl. A corresponding antibody was produced by inoculating rabbits with progesterone-11α-hemisuccinyl-(bovine serum albumin). These materials were then used in developing a method to measure progesterone.
R, Wei, R, Almirez
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The Biochemistry of Progesterone
1964Publisher Summary This chapter focuses on the progress that has been made in the knowledge of certain aspects of the biochemistry of progesterone in the past few years. The chapter discusses the secretion and metabolism of the hormone. The primary biological action of progesterone is on reproductive processes.
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Progesterone receptor and the mechanism of action of progesterone antagonists
The Journal of Steroid Biochemistry and Molecular Biology, 1995Currently available progesterone antagonists have been suggested to fall into two categories based on differences in how they interact with and inactivate the progesterone receptor (PR). The anti-progestin ZK98299 (Type I) impairs PR association with DNA, while Type II compounds (RU486, ZK112993, ZK98734) promote PR binding to DNA.
D P, Edwards +5 more
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Progesterone and the progesterone receptor.
The Journal of reproductive medicine, 2001During the 1990s, extensive research has effectively mapped the progesterone receptor-mediated actions of progesterone and has more recently uncovered nonreceptor-mediated effects--the effect of progesterone on uterine sensitivity to oxytocin, for example, involves direct, nongenomic progesterone action on the uterine oxytocin receptor.
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Progesterone antagonists and progesterone receptor modulators: an overview
Steroids, 2003Since the original description of the structure of the antiprogestin, mifepristone, was published, numerous related compounds have been synthesized which may function as progesterone antagonists (PAs) or progesterone receptor modulators (PRMs). The latter are mixed agonists-antagonists.
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