Results 41 to 50 of about 362,542 (345)

Progesterone for premenstrual syndrome [PDF]

Cochrane Database of Systematic Reviews, 2006
Premenstrual Syndrome (PMS) is the term for severe symptoms experienced by about 5% of menstruating women up to two weeks before their menstrual periods, but not at other times. Treatment with progesterone may restore a deficiency, or balance the level of progesterone with other menstrual hormones. Progesterone therapy may reduce the effects of falling
Ford, O., Lethaby, A., Roberts, H., Mol, B.   +3 more
openaire   +5 more sources

Estrogen and progesterone promote breast cancer cell proliferation by inducing cyclin G1 expression

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2018
Breast cancer is the most common cause of cancer among women in most countries (WHO). Ovarian hormone disorder is thought to be associated with breast tumorigenesis.
Jintao Tian, B. Ran, C. Zhang, D. Yan, X-H. Li   +4 more
semanticscholar   +1 more source

The high concentration of progesterone is harmful for endometrial receptivity and decidualization

Scientific Reports, 2018
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics.
Yu-Xiang Liang, Li Liu, Zhi-Yong Jin, Xiao-huan Liang, Yong-Sheng Fu, Xiaowei Gu, Zeng-Ming Yang   +6 more
semanticscholar   +1 more source

Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling

Scientific Reports, 2017
Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors.
Mayu Kasubuchi, Keita Watanabe, Kanako Hirano, Daisuke Inoue, Xuan Li, Kazuya Terasawa, Morichika Konishi, Nobuyuki Itoh, Ikuo Kimura   +8 more
doaj   +1 more source

Progesterone Metabolism by Human and Rat Hepatic and Intestinal Tissue

Pharmaceutics, 2021
Following oral administration, the bioavailability of progesterone is low and highly variable. As a result, no clinically relevant, natural progesterone oral formulation is available.
Zoe Coombes, Katie Plant, Cristina Freire, Abdul W. Basit, Philip Butler, R. Steven Conlan, Deyarina Gonzalez   +6 more
doaj   +1 more source

Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development

Gut Microbes
\Levels of progesterone, an endogenous female hormone, increase after ovulation; progesterone is crucial in the luteal phase to maintain successful pregnancy and prevent early miscarriage.
Mei-Jou Chen, Chia-Hung Chou, Tsun-Hsien Hsiao, Tien-Yu Wu, Chi-Ying Li, Yi-Lung Chen, Kuang-Han Chao, Tzong-Huei Lee, Ronnie G. Gicana, Chao-Jen Shih, Guo-Jie Brandon-Mong, Yi-Li Lai, Po-Ting Li, Yu-Lin Tseng, Po-Hsiang Wang, Yin-Ru Chiang   +15 more
doaj   +1 more source

Predictive Value of Serum Progesterone Levels on The Day of Frozen-Thawed Embryo Transfer in Determining Pregnancy Outcomes in Infertile Women: A Cohort Prospective Study [PDF]

International Journal of Fertility and Sterility
Background: Hormone replacement therapy (HRT) is the preferred protocol for endometrial preparation. Progesterone is important for successful implantation and the outcome of assisted reproductive techniques (ART).
Saeideh Dashti, Nasim Tabibnejad, Farimah Shamsi, Behnaz Gandom   +3 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Molecular evidence of functional progesterone withdrawal in human myometrium

Nature Communications, 2016
Progesterone suppresses uterine contractility acting through its receptors (PRA/B). The mechanism by which human labour is initiated in the presence of elevated circulating progesterone has remained an enigma since Csapo first theorized of a functional ...
Lubna Nadeem, O. Shynlova, E. Matysiak-Zablocki, S. Mesiano, Xuesen Dong, S. Lye   +5 more
semanticscholar   +1 more source