Results 41 to 50 of about 281,417 (260)
Gut Microbes\Levels of progesterone, an endogenous female hormone, increase after ovulation; progesterone is crucial in the luteal phase to maintain successful pregnancy and prevent early miscarriage.
Mei-Jou Chen +15 more
doaj +1 more source
Scientific Reports, 2017 Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors.
Mayu Kasubuchi +8 more
doaj +1 more source
Progesterone Inhibits Human Endothelial Cell Proliferation through a P53- Dependent Pathway
, 2009 Previous studies have shown that progesterone inhibits endothelial cell proliferation through a nuclear receptor- mediated mechanism. Here, we further demonstrate that progesterone at physiologic levels (5 - 500 nM) dose- and time-dependently inhibited ...
HSU, SUNG-PO;HO, PEI-YIN;JUAN, SHU-HUI;LIANG, YU-CHIH;LEE, WEN-SEN +1 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Predictive Value of Serum Progesterone Levels on The Day of Frozen-Thawed Embryo Transfer in Determining Pregnancy Outcomes in Infertile Women: A Cohort Prospective Study [PDF]
International Journal of Fertility and SterilityBackground: Hormone replacement therapy (HRT) is the preferred protocol for endometrial preparation. Progesterone is important for successful implantation and the outcome of assisted reproductive techniques (ART).
Saeideh Dashti +3 more
doaj +1 more source
The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium [PDF]
, 2008 Progesterone is indispensable for differentiation of human endometrial stromal cells (HESCs) into decidual cells, a process that critically controls embryo implantation.
Cartwright, JE +44 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Progesterone Metabolism by Human and Rat Hepatic and Intestinal Tissue
Pharmaceutics, 2021 Following oral administration, the bioavailability of progesterone is low and highly variable. As a result, no clinically relevant, natural progesterone oral formulation is available.
Zoe Coombes +6 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Effect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells [PDF]
, 1993 Oxytocin and its receptor are found in the corpus luteum in a variety of species, including the human. In the present study we used fura-2 microfluorimetry to investigate whether activation of the oxytocin receptor of cultured human granulosa-lutein ...
Wiemann, M. +4 more
core +1 more source