Results 31 to 40 of about 30,715 (288)

Prognostic factors of oncologic outcomes after fertility-preservative management with progestin in early-stage of endometrial cancer

Journal of Research in Medical Sciences, 2021
Background: The aim of this study was to evaluate efficacy of various fertility-preservative treatments with progestin and analyze prognostic factors in Stage 1A of endometrial cancer.
Hyun Jin Roh, Hyung Joon Yoon, Dae Hoon Jeong, Tae Hwa Lee, Byung Su Kwon, Dong Soo Suh, Ki Hyung Kim   +6 more
doaj   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Phosphorylation of IDH1 Facilitates Progestin Resistance in Endometrial Cancer

Advanced Science
The progestin regimen is one of the main therapeutic strategies for women with endometrial cancer who undergo conservative management. Although many patients respond well to initial therapy, progestin‐refractory disease inevitably emerges, and the ...
Jingjie Li, Zuoshu Qin, Yunqi Li, Baozhu Huang, Qimeng Xiao, Peiqin Chen, Yifan Luo, Wenxin Zheng, Tao Zhang, Zhenbo Zhang   +9 more
doaj   +1 more source

Advances in the molecular mechanisms underlying progestin resistance in endometrial cancer

Fundamental Research
The incidence of endometrial cancer (EC) has been on the rise, with a notable increase observed in younger female population. Approximately 80% of EC patients are associated with endometrial hyperplasia, a condition characterized by excessive stimulation
Jie Liu, Jingyi Zhou, Yiqin Wang, Fengxia Xue, Xiaojun Chen, Gang Chen, Jianliu Wang   +6 more
doaj   +1 more source

Systemic menopausal hormone therapy treatment patterns in Danish women—A nationwide drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Objectives This paper aims to describe the treatment patterns of contemporary systemic menopausal hormone therapy (MHT) in Denmark. Study design This study is a nationwide drug utilization study including an open cohort of all Danish women aged >40 years between 2000–2024.
Hannah K. Wood‐Kurland, Kathrine Kold Sørensen, Amalie Lykkemark Møller, Lina Steinrud Mørch, Mikkel Porsborg Andersen, Thomas Alexander Gerds, Amani Meaidi, Christian Torp‐Pedersen   +7 more
wiley   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Parenteral administration of medroxyprogesterone acetate in cats: A morphological and histopathological evaluation of ovaries

Journal of Advanced Biotechnology and Experimental Therapeutics
Fertility control measures aim to reduce reproduction and address the issue of overpopulation in pets. Progestins are among the most often utilized drugs for feline contraception, with Medroxyprogesterone acetate (MPA) being one of the most frequently ...
Md. Tasmir Rayan Labib, Robius Sani Sadi, Mousumi Saha, Md. Tuhinur Rahman, Sattwikesh Paul, Md. Abdullah Al Mahmud, Ziban Chandra Das, Abu Nasar Md. Aminoor Rahman, Md. Ataur Rahman   +8 more
doaj   +1 more source

Serotonin and the ventilatory effects of etonogestrel, a gonane progestin, in a murine model of congenital central hypoventilation syndrome

Frontiers in Endocrinology, 2023
IntroductionCongenital Central Hypoventilation Syndrome, a rare disease caused by PHOX2B mutation, is associated with absent or blunted CO2/H+ chemosensitivity due to the dysfunction of PHOX2B neurons of the retrotrapezoid nucleus.
Alexis Casciato, Lola Bianchi, Manon Reverdy, Fanny Joubert, Roman Delucenay-Clarke, Sandrine Parrot, Nélina Ramanantsoa, Eléonore Sizun, Boris Matrot, Christian Straus, Thomas Similowski, Florence Cayetanot, Laurence Bodineau   +12 more
doaj   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Progestin therapy in endometriosis

, 2015
Progestins are synthetic compounds that mimic the effects of progesteron. For over 50 years, oral progestins have been demonstrated to be effective in the treatment of endometriosis.
Oral, Engin, Gezer, Altay
core   +1 more source