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A drug-drug interaction study to evaluate the effects of strong CYP3A4 inducer on the pharmacokinetics of segesterone acetate and ethinyl estradiol in a contraceptive vaginal system. [PDF]
Contracept Reprod MedPlagianos M +8 more
europepmc +1 more source
EndoCompass Project: Research Roadmap for Endocrine Causes and Consequences of Cancers.
Horm Res PaediatrCarroll JS +14 more
europepmc +1 more source
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Maturitas, 1996
The history of progesterone and hormone replacement therapy goes back to 1934 when Butenandt obtained crystalline progesterone and Kaufmann started to treat ovariectomized women with both estrogens and progesterone (Table 1). Today synthetic perorally active 19-nortestosterone and 17-alpha-hydroxyprogesterone derivatives are used in addition to ...
openaire +2 more sources
The history of progesterone and hormone replacement therapy goes back to 1934 when Butenandt obtained crystalline progesterone and Kaufmann started to treat ovariectomized women with both estrogens and progesterone (Table 1). Today synthetic perorally active 19-nortestosterone and 17-alpha-hydroxyprogesterone derivatives are used in addition to ...
openaire +2 more sources
Steroids, 2000
Progestin implants for contraception are highly effective, safe, and the most convenient choice for many women. Progestin implants currently on the market, preparing for launch, or under investigation are reviewed here. Their basic galenic and pharmacokinetic features, as well as their contraceptive effectiveness, are described.
openaire +2 more sources
Progestin implants for contraception are highly effective, safe, and the most convenient choice for many women. Progestin implants currently on the market, preparing for launch, or under investigation are reviewed here. Their basic galenic and pharmacokinetic features, as well as their contraceptive effectiveness, are described.
openaire +2 more sources
Journal of Midwifery & Women's Health, 2002
ABSTRACTProgestin contraceptives offer unique advantages, allowing the clinician to tailor optimum regimens for selected women. This article reviews the various progestational drugs, regimens, and delivery systems available presently and in development, with reference to the clinical benefits and limitations of each method.
openaire +2 more sources
ABSTRACTProgestin contraceptives offer unique advantages, allowing the clinician to tailor optimum regimens for selected women. This article reviews the various progestational drugs, regimens, and delivery systems available presently and in development, with reference to the clinical benefits and limitations of each method.
openaire +2 more sources
Molecular Biology, 2016
Progesterone and its analogs may exert opposite effects on cell proliferation, apoptosis, and epithelial-mesenchymal transition, leading to higher cell motility and metastasis. Their ultimate effect is determined by a number of factors: the structure and concentration of the steroid, its affinity for various forms of steroid hormone receptors ...
T A, Shchelkunova, I A, Morozov
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Progesterone and its analogs may exert opposite effects on cell proliferation, apoptosis, and epithelial-mesenchymal transition, leading to higher cell motility and metastasis. Their ultimate effect is determined by a number of factors: the structure and concentration of the steroid, its affinity for various forms of steroid hormone receptors ...
T A, Shchelkunova, I A, Morozov
openaire +2 more sources
Clinical pharmacology of progestins
Minerva Obstetrics and Gynecology, 2022In this paper, we report general pharmacological profile and major biological activities of natural progesterone (P) and progestins. The aim of this article consists of synthesizing the principal aspects of pharmacology and metabolism of P and progestins related to the clinical consequences of their use.We review scientific literature on the topic ...
Capozzi, Anna +2 more
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Estrogen-progestins and progestins for the management of endometriosis
Fertility and Sterility, 2016Endometriosis is characterized by frequent recurrences of symptoms and lesions even after extirpative surgery. Because medical therapies control but do not cure the disease, long periods of pharmacologic management may be needed until pregnancy desire or, sometimes, physiologic menopause.
P. Vercellini +5 more
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